4,7-Dichloroquinoline
- CAS No.86-98-6
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 4,7-Dichloroquinoline (CAS 86-98-6), a key pharmaceutical intermediate for antimalarial and heterocyclic compound synthesis. Assay ≥99.0%, manufactured at 20-ton monthly capacity in China.
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Product Overview
4,7-Dichloroquinoline is a critical heterocyclic building block widely employed in the synthesis of advanced pharmaceutical intermediates, particularly in the development of antimalarial agents and other nitrogen-containing bioactive molecules. As a high-value quinoline derivative, it serves as a foundational scaffold in multi-step organic syntheses requiring regioselective functionalization.
Specifications
| Appearance | Light yellow solid or light yellow crystalline solid |
|---|---|
| Melting Point | 83–87 °C |
| Assay (GC/HPLC) | ≥99.0% |
| Moisture (Karl Fischer) | ≤1.0% |
| 4,5-Dichloroquinoline | ≤0.5% |
| 7-Chloro-4-hydroxyquinoline | ≤0.3% |
| Other Single Impurities | ≤0.5% |
Industrial Applications
This compound is primarily utilized as a synthetic intermediate in the pharmaceutical industry. Its dual chlorine substitution pattern enables selective nucleophilic aromatic substitution reactions, facilitating the construction of complex molecular architectures. Key application areas include:
- Synthesis of chloroquine-related antimalarial drug candidates
- Preparation of kinase inhibitors and other targeted therapeutics
- Building block for fluorescent probes and agrochemical research
- Intermediate in the production of specialty ligands for catalysis
Manufactured under stringent quality control systems compliant with international GMP guidelines, our 4,7-Dichloroquinoline is produced at a scale of 20 metric tons per month, ensuring reliable supply for global API manufacturers and R&D institutions.
