Intermediates

4-Amino-2-Chloro-6-(Trifluoromethyl)Pyridine

  • CAS No.34486-22-1
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High purity 4-Amino-2-chloro-6-(trifluoromethyl)pyridine is a premium fluorinated heterocyclic intermediate designed for advanced organic synthesis and pharmaceutical research applications.

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Product Technical Details

Product Overview

4-Amino-2-Chloro-6-(Trifluoromethyl)Pyridine is a highly specialized fluorinated heterocyclic compound that serves as a critical building block in modern organic synthesis. Characterized by its unique pyridine structure substituted with amino, chloro, and trifluoromethyl groups, this chemical intermediate offers exceptional reactivity and stability for complex molecular constructions. Our facility produces this compound under strict quality control protocols to ensure consistency across batches, making it an ideal choice for research and development teams focused on medicinal chemistry and agrochemical innovation.

The presence of the trifluoromethyl group significantly enhances the lipophilicity and metabolic stability of downstream molecules, which is a key requirement in contemporary drug design. As a trusted global manufacturer, we understand the precise demands of synthetic chemists and provide material that meets rigorous analytical standards. This product is specifically engineered to facilitate nucleophilic substitution reactions and cross-coupling processes, enabling the efficient synthesis of high-value target compounds.

Quality Specifications

We maintain a commitment to excellence by subjecting every production lot to comprehensive analytical testing. Our quality assurance team utilizes advanced instrumentation, including HPLC and NMR spectroscopy, to verify chemical identity and purity levels. The following table outlines the key physical and chemical parameters associated with this product:

ParameterSpecification
CAS Number34486-22-1
Molecular FormulaC6H4ClF3N2
Molecular Weight196.558 g/mol
AppearanceWhite to off-white crystalline powder
Assay (Purity)≥98.0%
Density1.5±0.1 g/cm3
Boiling Point261.0±40.0 °C at 760 mmHg
Flash Point111.7±27.3 °C
Refractive Index1.502

Industrial Applications

This fluorinated pyridine derivative is primarily utilized as a versatile intermediate in the preparation of pharmaceuticals, agrochemicals, and functional materials. Its structural features allow it to act as a precursor for various biologically active molecules. Common application areas include the synthesis of kinase inhibitors, receptor modulators, and specialized herbicides. The chloro and amino functionalities provide multiple sites for further derivatization, offering synthetic flexibility for chemists designing novel molecular architectures.

Furthermore, this compound is valuable in the development of new materials where specific electronic properties are required. The trifluoromethyl group imparts distinct electronic effects that can influence the binding affinity and pharmacokinetic profiles of final drug candidates. Our clients leverage this intermediate to accelerate their discovery pipelines while maintaining high standards of chemical integrity.

Storage and Handling

To preserve the integrity of 4-Amino-2-Chloro-6-(Trifluoromethyl)Pyridine, proper storage conditions are essential. The material should be kept in a cool, ventilated area away from direct sunlight and moisture. Containers must remain tightly sealed when not in use to prevent contamination or degradation. We recommend standard laboratory safety practices during handling, including the use of appropriate personal protective equipment. Our packaging options include 25 kg drums, with custom packaging available upon request to suit specific logistical requirements.

Why Choose Our Supply

Partnering with us ensures access to a reliable supply chain backed by decades of chemical manufacturing expertise. We offer competitive bulk pricing without compromising on quality. Each shipment is accompanied by a comprehensive Certificate of Analysis (COA) to verify compliance with specified parameters. Our technical support team is available to assist with application queries and provide documentation necessary for regulatory submissions. Choose us for your fluorinated intermediate needs and experience the difference of working with a dedicated industry leader.