Intermediates

4-Amino-2-fluorobenzonitrile

  • CAS No.53312-80-4
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 4-Amino-2-fluorobenzonitrile (CAS 53312-80-4) designed for advanced organic synthesis. Reliable supply with ≥98.0% assay for pharmaceutical and agrochemical manufacturing.

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Product Technical Details

Product Overview

4-Amino-2-fluorobenzonitrile represents a critical fluorinated building block within the realm of modern organic chemistry. As a specialized intermediate, this compound is engineered to meet the rigorous demands of pharmaceutical and agrochemical research and development. Our manufacturing process ensures that every batch delivers consistent molecular integrity, making it an ideal candidate for complex synthesis routes where precision is paramount. The introduction of a fluorine atom at the ortho position relative to the nitrile group significantly alters the electronic properties of the benzene ring, thereby enhancing its reactivity in nucleophilic substitution reactions.

We understand that reliability in the supply chain is just as important as chemical purity. Therefore, our production facilities adhere to strict quality management systems to guarantee that this material is available for large-scale industrial applications without compromise. Whether utilized in the construction of heterocyclic frameworks or as a precursor for active pharmaceutical ingredients, this substance provides a stable foundation for downstream chemical transformations.

Technical Specifications

Quality control is the cornerstone of our operation. Each lot undergoes comprehensive analytical testing to verify compliance with established standards. The physical and chemical properties listed below are representative of our standard commercial grade, ensuring transparency for our procurement partners and technical teams.

ParameterSpecification
CAS Number53312-80-4
Molecular FormulaC7H5FN2
Molecular Weight136.126 g/mol
AppearanceOff-white to yellow powder
Assay (Purity)≥98.0%
Density1.3±0.1 g/cm3
Boiling Point288.2±25.0 °C at 760 mmHg
Flash Point128.1±23.2 °C
Refractive Index1.560

Industrial Applications

This fluorinated nitrile derivative serves as a versatile intermediate in the synthesis of various high-value chemicals. Its primary utility lies in the formation of carbon-nitrogen and carbon-carbon bonds under controlled conditions. Researchers frequently employ this compound in the development of novel therapeutic agents where fluorine substitution is known to improve metabolic stability and bioavailability. Additionally, it finds application in the agrochemical sector for the production of herbicides and pesticides that require specific electronic configurations for optimal activity.

The versatility of 4-Amino-2-fluorobenzonitrile allows it to participate in a wide array of reactions, including cyclization, reduction, and coupling processes. Its stability under standard storage conditions makes it suitable for global distribution, ensuring that laboratories and manufacturing plants worldwide can access high-quality raw materials without logistical delays. Our technical team is available to provide guidance on optimal reaction conditions to maximize yield and minimize byproduct formation.

Storage and Handling

To maintain the integrity of the product, proper storage protocols must be observed. The material should be kept in a cool, ventilated area away from direct sunlight and sources of ignition. Containers must remain tightly sealed when not in use to prevent moisture absorption or contamination from atmospheric particulates. We recommend using appropriate personal protective equipment during handling to ensure safety in the workplace. Our packaging options include standard 25 kg drums, with flexibility to accommodate custom requirements based on volume needs and shipping regulations.