Intermediates

4-Amino-3-chlorophenol Hydrochloride

  • CAS No.52671-64-4
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 4-Amino-3-chlorophenol Hydrochloride (CAS 52671-64-4) designed for pharmaceutical synthesis. Ideal intermediate for Lenvatinib production with ≥98.0% assay.

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Product Technical Details

Product Overview

4-Amino-3-chlorophenol Hydrochloride is a specialized organic compound widely utilized in the pharmaceutical industry as a critical building block for complex medicinal synthesis. As a hydrochloride salt, this substance offers enhanced stability and solubility characteristics compared to its free base form, making it particularly suitable for precise chemical reactions required in modern drug development. Our manufacturing process ensures that each batch meets stringent quality standards, providing reliability for downstream synthesis operations.

This chemical intermediate plays a pivotal role in the production of kinase inhibitors and other advanced therapeutic agents. The presence of both amino and chloro substituents on the phenol ring allows for versatile functionalization, enabling chemists to construct sophisticated molecular architectures efficiently. We prioritize consistency and purity to support seamless integration into your production lines.

Key Specifications

Quality control is paramount in pharmaceutical intermediate manufacturing. We employ advanced analytical techniques, including High-Performance Liquid Chromatography (HPLC), to verify the composition and purity of every lot. The following table outlines the standard technical parameters for this product:

ParameterSpecification
Chemical Name4-Amino-3-chlorophenol Hydrochloride
CAS Number52671-64-4
Molecular FormulaC6H7Cl2NO
Molecular Weight180.03 g/mol
AppearanceOff-white crystalline powder
Purity (HPLC)≥98.0%
Loss on Drying≤1.0%
Melting Point255°C

Industrial Applications

The primary application of 4-Amino-3-chlorophenol Hydrochloride is serving as a key intermediate in the synthesis of Lenvatinib, a multi-kinase inhibitor used in oncology treatments. Its specific structural configuration allows for selective coupling reactions that are essential for forming the core structure of such targeted therapies. Beyond this specific use, it is also valuable in the research and development of novel aromatic compounds and agrochemical formulations.

Our clients benefit from a supply chain optimized for industrial scale. Whether for pilot plant studies or full-scale commercial production, our material consistency ensures reproducible results. We understand the critical nature of supply continuity in the pharmaceutical sector and maintain robust inventory levels to meet global demand.

Storage and Handling

To maintain the integrity of 4-Amino-3-chlorophenol Hydrochloride, proper storage conditions are essential. The product should be kept in a cool, ventilated area away from direct sunlight and moisture sources. Containers must be tightly sealed when not in use to prevent hydration or contamination. Standard safety protocols for handling fine chemical powders should be followed, including the use of appropriate personal protective equipment.

We offer flexible packaging options, typically supplying in 25 kg drums, but can accommodate specific customer requirements for larger bulk shipments. Each shipment is accompanied by a Certificate of Analysis (COA) to verify compliance with specified parameters. For international transport, the product is classified under HS Code 2922299090, ensuring smooth customs clearance processes.