Intermediates

4-Amino-3-fluorobenzoic acid

  • CAS No.455-87-8
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 4-Amino-3-fluorobenzoic acid (CAS 455-87-8) designed for advanced organic synthesis and pharmaceutical intermediate applications.

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Product Technical Details

Product Overview

4-Amino-3-fluorobenzoic acid is a specialized fluorinated aromatic compound that serves as a critical building block in modern medicinal chemistry and organic synthesis. Characterized by the presence of both amino and carboxylic acid functional groups on a fluorinated benzene ring, this molecule offers unique reactivity profiles that are highly valued in the development of complex pharmaceutical agents. The introduction of fluorine at the meta-position relative to the carboxyl group enhances metabolic stability and lipophilicity in downstream drug candidates, making this intermediate a preferred choice for research and industrial production teams.

Our manufacturing process ensures consistent quality and high purity levels, adhering to strict international standards for chemical intermediates. This product is extensively utilized in the synthesis of quinolone antibiotics, kinase inhibitors, and other therapeutic categories where fluorinated scaffolds are required. As a dedicated supplier, we prioritize supply chain reliability to support continuous production schedules for our global partners.

Technical Specifications

ParameterSpecification
Chemical Name4-Amino-3-fluorobenzoic acid
CAS Number455-87-8
Molecular FormulaC7H6FNO2
Molecular Weight155.126 g/mol
AppearanceWhite to light yellow crystals
Assay (Purity)≥98.0%
Melting Point215-218°C
Density1.4±0.1 g/cm3
Boiling Point320.8±27.0 °C at 760 mmHg
Flash Point147.8±23.7 °C

Industrial Applications

This fluorinated benzoic acid derivative is primarily employed as a key intermediate in the preparation of active pharmaceutical ingredients (APIs). Its structural features allow for versatile chemical transformations, including amidation, esterification, and cross-coupling reactions. The specific placement of the fluorine atom facilitates nucleophilic aromatic substitution, enabling chemists to construct complex molecular architectures efficiently.

  • Pharmaceutical Intermediate: Essential for synthesizing fluoroquinolone antibiotics and anticancer agents.
  • Organic Synthesis: Used as a starting material for creating novel fluorinated heterocycles.
  • Research and Development: Supports drug discovery programs requiring high-purity building blocks.
  • Custom Synthesis: Available for bespoke chemical manufacturing projects requiring specific purity profiles.

Quality Assurance and Storage

We maintain a robust quality control system to guarantee that every batch meets the specified assay requirements. Each shipment is accompanied by a Certificate of Analysis (COA) detailing physical and chemical properties. To maintain stability, the product should be stored in a cool, ventilated place away from direct sunlight and moisture. Packaging is available in 25 kg drums, with flexible options to accommodate specific customer logistics requirements. Our commitment to safety and compliance ensures that all handling guidelines are clearly communicated to facilitate safe industrial use.