4-(4-Amino-3-fluorophenoxy)-N-methylpicolinamide

Product Overview

4-(4-Amino-3-fluorophenoxy)-N-methylpicolinamide represents a critical advanced intermediate in the pharmaceutical industry, specifically designed for the synthesis of kinase inhibitors. This sophisticated organic compound features a fluorinated phenoxy group linked to a methylated picolinamide core, providing unique chemical reactivity and stability required for complex drug manufacturing processes. Our facility produces this material under strict quality control standards to ensure consistency across large-scale batches.

As a specialized chemical entity, this compound plays a pivotal role in the production chain of targeted cancer therapies. The presence of the fluorine atom enhances metabolic stability and bioavailability in the final drug product, making the purity of this intermediate paramount. We utilize advanced catalytic hydrogenation and amidation techniques to achieve superior assay levels while minimizing impurities that could affect downstream reactions.

Technical Specifications

Our manufacturing process adheres to rigorous industrial standards to guarantee that every batch meets the required physical and chemical properties. The following table outlines the key specifications for this product, ensuring compatibility with various synthesis routes used by our global partners.

Applications and Usage

This chemical is primarily utilized as a building block in the multi-step synthesis of Regorafenib, a potent multi-kinase inhibitor. The high purity grade ensures efficient coupling reactions and reduces the need for extensive purification in later stages. Pharmaceutical manufacturers rely on this intermediate for its consistent performance in nucleophilic substitution and amide bond formation.

• Key intermediate for oncology drug synthesis
• Suitable for large-scale industrial manufacturing
• Compatible with standard organic synthesis protocols
• Optimized for high-yield coupling reactions

Quality Assurance and Packaging

Quality is the cornerstone of our operation. Each batch undergoes comprehensive testing using HPLC, NMR, and mass spectrometry to verify identity and purity. We provide a detailed Certificate of Analysis (COA) with every shipment, documenting all critical quality attributes. Our packaging solutions are designed to maintain product integrity during transit and storage.

Standard packaging includes 25 kg drums, though we offer flexible customization to meet specific logistical requirements. Storage recommendations include keeping the material in a cool, ventilated area away from direct sunlight and moisture. As a trusted global manufacturer, we ensure reliable supply chains and competitive bulk pricing for long-term partnerships.