Intermediates

4-Amino-3-fluoropyridine

  • CAS No.2247-88-3
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 4-Amino-3-fluoropyridine (CAS 2247-88-3) designed for advanced pharmaceutical synthesis. Reliable supply with strict quality control for global medicinal chemistry projects.

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Product Technical Details

Product Overview

4-Amino-3-fluoropyridine represents a critical heterocyclic building block within the realm of modern medicinal chemistry. As a fluorinated pyridine derivative, this compound offers unique electronic and steric properties that are highly valued in the design and synthesis of complex pharmaceutical active ingredients. The introduction of a fluorine atom at the third position of the pyridine ring significantly enhances metabolic stability and bioavailability in downstream drug candidates. Our facility specializes in the production of this key intermediate, ensuring that every batch meets rigorous international standards for purity and consistency.

We understand that the reliability of your supply chain is paramount to your research and development timelines. Therefore, our manufacturing process is optimized to deliver high yields while maintaining exceptional chemical integrity. This product serves as a versatile nucleophile or electrophile partner in various coupling reactions, making it indispensable for the construction of kinase inhibitors, antiviral agents, and other therapeutic modalities. By choosing our supply, you gain access to a material that facilitates efficient synthetic routes and reduces overall production costs for your final formulations.

Technical Specifications

To guarantee performance in sensitive synthetic applications, we adhere to strict analytical protocols. The following table outlines the key physical and chemical parameters verified during our quality control process. Each certificate of analysis provides detailed data confirming compliance with these specifications.

ParameterSpecification
CAS Number2247-88-3
Molecular FormulaC5H5FN2
Molecular Weight112.11 g/mol
AppearanceYellow crystals
Purity≥99.0%
Melting Point74-77°C
Boiling Point217.1±20.0 °C
Density1.3±0.1 g/cm3

Industrial Applications

The primary utility of 4-Amino-3-fluoropyridine lies in its role as a pharmaceutical intermediate. It is extensively utilized in the multistep synthesis of novel drug entities where the pyridine scaffold is a core structural element. The amino group allows for further functionalization through acylation, alkylation, or cross-coupling reactions, while the fluorine substituent modulates the electronic environment of the ring system. Beyond human pharmaceuticals, this chemical finds applications in agrochemical research and material science, where fluorinated heterocycles are increasingly demanded for their specific performance characteristics.

Our clients leverage this building block to accelerate their discovery pipelines. Whether you are developing small molecule therapeutics or conducting structure-activity relationship studies, the high purity of our material ensures that side reactions are minimized. This reliability is crucial when scaling up from laboratory benchtop synthesis to pilot plant operations. We support diverse research needs by providing consistent quality that aligns with the demanding requirements of global regulatory bodies.

Quality Assurance and Logistics

Quality is the cornerstone of our operation. Every production batch undergoes comprehensive testing using advanced chromatographic and spectroscopic methods. We provide full documentation, including Certificates of Analysis and Material Safety Data Sheets, with every shipment. Our packaging options are designed to maintain product stability during transit, utilizing aluminum foil bags, fluoride bottles, or fiber drums depending on the order volume. We store all inventory in controlled environments to prevent degradation from moisture or heat.

As a global manufacturer, we are committed to timely delivery and responsive customer service. Our logistics network ensures that orders are processed efficiently and shipped securely to destinations worldwide. We understand the complexities of international chemical trade and handle all necessary documentation to facilitate smooth customs clearance. For bulk requirements, we offer competitive pricing structures without compromising on quality. Partner with us for a reliable source of 4-Amino-3-fluoropyridine that supports your innovation and growth in the competitive pharmaceutical landscape.