Intermediates

4-Amino-3-nitropyridine

  • CAS No.1681-37-4
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 4-Amino-3-nitropyridine (CAS 1681-37-4) is a critical heterocyclic intermediate designed for advanced pharmaceutical and agrochemical synthesis processes.

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Product Technical Details

Product Overview

4-Amino-3-nitropyridine is a specialized heterocyclic compound that serves as a vital building block in modern organic synthesis. Characterized by its unique pyridine ring structure substituted with amino and nitro groups, this chemical intermediate offers exceptional reactivity for downstream derivatization. Our manufacturing process ensures consistent molecular integrity, making it an ideal choice for research laboratories and industrial production facilities focused on developing novel pharmaceutical agents and agrochemical solutions.

As a key precursor, this compound facilitates the construction of complex molecular architectures required in medicinal chemistry. The presence of both electron-donating and electron-withdrawing groups on the pyridine ring allows for versatile synthetic transformations, enabling chemists to achieve high yields in coupling reactions and functional group modifications.

Technical Specifications

ParameterSpecification
Chemical Name4-Amino-3-nitropyridine
CAS Number1681-37-4
Molecular FormulaC5H5N3O2
Molecular Weight139.11 g/mol
AppearanceOff-white to yellow powder
Purity (GC)≥98.0%
Melting Point203-207°C
Density1.437 g/cm³

Industrial Applications

This intermediate is extensively utilized in the synthesis of active pharmaceutical ingredients (APIs) where pyridine derivatives are required. Its high purity profile supports stringent quality control standards necessary for drug development pipelines. Additionally, it finds application in the agrochemical sector for producing herbicides and pesticides that rely on nitrogen-containing heterocycles for biological activity.

Beyond traditional pharmaceuticals, 4-Amino-3-nitropyridine is employed in material science research for developing functional polymers and organic electronic materials. The stability of the nitro group under specific conditions allows for controlled reduction steps, providing access to diamino derivatives used in cross-linking agents and specialty coatings.

Quality Assurance and Handling

Every batch undergoes rigorous analytical testing using gas chromatography and spectroscopic methods to verify identity and purity levels. We provide comprehensive Certificates of Analysis (COA) with each shipment to ensure full traceability and compliance with international chemical safety standards. Our quality management system guarantees that product specifications remain within tight tolerances suitable for sensitive synthetic applications.

For safe handling, store this material in a cool, ventilated area away from incompatible substances such as strong oxidizing agents. Packaging is available in 25 kg drums, with custom options available upon request to suit specific logistical requirements. Proper personal protective equipment should be worn during handling to prevent inhalation or skin contact, adhering to standard laboratory safety protocols.