Intermediates

4-Benzyl-2-hydroxymorpholin-3-one

  • CAS No.287930-73-8
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity pharmaceutical intermediate used in the synthesis of Fosaprepitant dimeglumine. Available in bulk quantities with full quality documentation.

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Product Technical Details

Product Overview

4-Benzyl-2-hydroxymorpholin-3-one is a specialized organic compound recognized for its critical role in modern pharmaceutical synthesis. As a key morpholinone derivative, this substance serves as an essential building block in the production of advanced antiemetic medications. Our facility produces this intermediate under strict quality control protocols to ensure consistency and reliability for downstream API manufacturing. The compound is characterized by its stable chemical structure and high reactivity profile, making it ideal for complex coupling reactions required in medicinal chemistry.

Technical Specifications

ParameterValue
CAS Number287930-73-8
Molecular FormulaC11H13NO3
Molecular Weight207.23 g/mol
Purity≥99.0%
AppearanceWhite powder
Density1.292 g/cm3
Boiling Point441.7°C at 760 mmHg
Flash Point220.9°C

Industrial Applications

This chemical is primarily utilized as a pivotal intermediate in the synthesis of Fosaprepitant dimeglumine, a widely prescribed medication used to prevent nausea and vomiting associated with chemotherapy. The high purity level of our 4-Benzyl-2-hydroxymorpholin-3-one ensures minimal impurity carryover into the final active pharmaceutical ingredient. This reduces purification burdens during later synthesis stages and enhances overall yield efficiency. Pharmaceutical manufacturers rely on this building block for its predictable performance in stereoselective reactions and its compatibility with various catalytic systems.

Quality Assurance

We maintain a robust quality management system compliant with international industry standards. Every batch undergoes rigorous analytical testing using HPLC, NMR, and mass spectrometry to verify identity and purity. We provide comprehensive documentation including Certificates of Analysis (COA) and Material Safety Data Sheets (MSDS) with every shipment. Our production process is designed to minimize batch-to-batch variation, ensuring that your manufacturing workflow remains uninterrupted. Continuous monitoring of critical process parameters allows us to deliver material that consistently meets or exceeds specification limits.

Storage and Handling

To maintain optimal stability, this product should be stored in a cool, dry, and well-ventilated area. Containers must remain tightly closed to prevent exposure to moisture and strong light. The material is sensitive to heat, so storage temperatures should be controlled according to standard warehouse protocols for fine chemicals. We recommend using appropriate personal protective equipment during handling, including gloves and safety goggles. Our packaging options include 25kg cardboard drums or custom configurations based on specific client logistics requirements. Global shipping capabilities ensure timely delivery to support your production schedules.