Intermediates

4-Bromo-2,3-difluorophenol

  • CAS No.144292-32-0
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High purity 4-Bromo-2,3-difluorophenol (CAS 144292-32-0) designed for advanced organic synthesis. Reliable supply with ≥98.0% assay guarantee for global pharmaceutical projects.

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Product Technical Details

Product Overview

4-Bromo-2,3-difluorophenol represents a critical fluorinated building block within the realm of modern organic synthesis. As a specialized intermediate, this compound combines the reactivity of a bromo substituent with the electronic influence of dual fluorine atoms on a phenolic ring. This unique structural configuration makes it an invaluable asset for medicinal chemists and process researchers aiming to develop novel pharmaceutical agents or advanced agrochemical formulations. Our manufacturing facility ensures that every batch meets rigorous international standards for purity and consistency.

The presence of fluorine atoms often enhances the metabolic stability and lipophilicity of final drug candidates, while the bromine group offers a versatile handle for cross-coupling reactions such as Suzuki or Buchwald-Hartwig transformations. Consequently, this material serves as a foundational precursor for constructing complex molecular architectures required in next-generation therapeutics.

Technical Specifications

ParameterSpecification
Chemical Name4-Bromo-2,3-difluorophenol
CAS Number144292-32-0
Molecular FormulaC6H3BrF2O
Molecular Weight208.988 g/mol
AppearanceOff-white to light yellow crystalline powder
Assay (Purity)≥98.0%
Melting Point49-52°C
Boiling Point213.3±35.0 °C at 760 mmHg
Density1.9±0.1 g/cm3
Refractive Index1.550

Industrial Applications

This fluorinated phenol derivative is primarily utilized as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs). Its specific substitution pattern allows for selective functionalization, enabling chemists to introduce diverse chemical groups with high precision. Beyond pharmaceuticals, it finds application in the development of high-performance polymers and liquid crystal materials where thermal stability and specific electronic properties are paramount.

Researchers value this compound for its reliability in multi-step synthesis routes. The high purity level minimizes side reactions, thereby improving overall yield and reducing downstream purification costs. Whether used in laboratory-scale discovery or pilot plant production, 4-Bromo-2,3-difluorophenol provides a consistent foundation for chemical innovation.

Quality Assurance And Packaging

Quality control is the cornerstone of our production process. Each batch undergoes comprehensive analysis using advanced techniques including High-Performance Liquid Chromatography (HPLC) and Nuclear Magnetic Resonance (NMR) spectroscopy. We provide a detailed Certificate of Analysis (COA) with every shipment to verify compliance with stated specifications. Our commitment to quality ensures that your research and production timelines remain uninterrupted.

Standard packaging consists of 25 kg drums, designed to maintain product integrity during transit. However, we understand that different projects have varying requirements. Therefore, we offer flexible packaging solutions tailored to specific customer needs. All containers are clearly labeled with safety information and batch numbers for full traceability.

Storage And Handling

To preserve the chemical stability of 4-Bromo-2,3-difluorophenol, proper storage conditions are essential. The material should be stored in a cool, ventilated area away from direct sunlight and moisture. Containers must remain tightly sealed when not in use to prevent contamination or degradation. Personnel handling this compound should adhere to standard laboratory safety protocols, including the use of appropriate personal protective equipment (PPE) such as gloves and safety goggles. By following these guidelines, users can ensure safe and effective utilization of this high-value chemical intermediate.