4-Bromo-2-fluorobenzonitrile

Product Overview

4-Bromo-2-fluorobenzonitrile is a highly specialized fluorinated aromatic compound that serves as a critical building block in modern organic synthesis. Characterized by its unique substitution pattern featuring both bromine and fluorine atoms on the benzene ring, this chemical offers versatile reactivity profiles suitable for complex molecular construction. Our facility produces this intermediate under strict quality control standards to ensure consistency for downstream pharmaceutical and agrochemical applications. The presence of the nitrile group further enhances its utility in various transformation reactions, making it a preferred choice for research and industrial scale manufacturing.

Key Specifications

Physical and Chemical Properties

Understanding the physicochemical characteristics of 4-Bromo-2-fluorobenzonitrile is essential for safe handling and process optimization. The compound exhibits a molecular formula of C7H3BrFN with a molecular weight of approximately 200.01 g/mol. It possesses a density of 1.7±0.1 g/cm3 and a melting point range between 69 to 72 degrees Celsius. The boiling point is recorded at 231.8±20.0 degrees Celsius at 760 mmHg, indicating stability under standard processing conditions. With a flash point of 94.0±21.8 degrees Celsius, appropriate safety measures should be maintained during storage and transport. The compound is insoluble in water, which facilitates specific extraction and purification protocols during synthesis workflows.

Industrial Applications

This fluorinated intermediate is extensively utilized in the development of active pharmaceutical ingredients (APIs) and fine chemicals. The bromine atom allows for palladium-catalyzed cross-coupling reactions such as Suzuki or Buchwald-Hartwig couplings, while the fluorine substituent can influence metabolic stability and bioavailability in drug candidates. Common applications include the synthesis of kinase inhibitors, receptor modulators, and specialized agrochemical agents. Our clients leverage this material for nucleophilic aromatic substitution reactions where the fluorine position offers selective reactivity. The high purity grade ensures minimal byproduct formation, reducing downstream purification costs and improving overall yield efficiency.

Quality Assurance and Storage

We adhere to rigorous manufacturing processes to maintain industrial purity levels. Each batch is accompanied by a Certificate of Analysis (COA) verifying identity and assay values. For optimal preservation, store this material in a cool, ventilated place away from direct sunlight and oxidizing agents. Containers should remain tightly sealed when not in use to prevent moisture absorption. We offer flexible packaging solutions including 25 kg drums or custom configurations based on specific logistical requirements. Our global supply chain ensures reliable delivery times for bulk orders, supporting continuous production schedules for our partners worldwide.