4-Bromo-2-fluoropyridine
- CAS No.128071-98-7
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 4-Bromo-2-fluoropyridine (CAS 128071-98-7) designed for advanced pharmaceutical synthesis. Reliable supply with strict quality control for global research and production needs.
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Product Overview
4-Bromo-2-fluoropyridine is a highly specialized halogenated heterocyclic compound that serves as a critical building block in modern medicinal chemistry and organic synthesis. Characterized by its unique substitution pattern featuring both bromine and fluorine atoms on the pyridine ring, this molecule offers exceptional reactivity for various cross-coupling reactions and nucleophilic substitutions. Our manufacturing process ensures consistent quality and high purity levels, making it an ideal choice for researchers and production facilities focused on developing advanced pharmaceutical intermediates.
The strategic positioning of the halogen atoms allows for selective functionalization, enabling chemists to construct complex molecular architectures efficiently. This compound is particularly valued in the synthesis of kinase inhibitors, agrochemicals, and other bioactive molecules where precise structural modification is required. We adhere to rigorous quality management systems to guarantee that every batch meets the demanding specifications of the global pharmaceutical industry.
Technical Specifications
| Property | Specification |
|---|---|
| CAS Number | 128071-98-7 |
| Molecular Formula | C5H3BrFN |
| Molecular Weight | 175.99 g/mol |
| Appearance | Colorless to light yellow liquid |
| Purity | ≥98.0% |
| Density | 1.7±0.1 g/cm3 |
| Boiling Point | 195.9±20.0 °C at 760 mmHg |
| Flash Point | 72.3±21.8 °C |
| Refractive Index | 1.534 |
Industrial Applications
This fluorinated pyridine derivative is extensively utilized in the preparation of diverse pharmaceutical agents. Its primary application lies in serving as a key intermediate for palladium-catalyzed coupling reactions, such as Suzuki, Heck, and Sonogashira couplings. The presence of the fluorine atom enhances metabolic stability and bioavailability in final drug candidates, while the bromine site offers a robust handle for further chemical transformation.
- Development of novel therapeutic agents targeting central nervous system disorders.
- Synthesis of agrochemical compounds requiring heterocyclic scaffolds.
- Construction of liquid crystals and advanced material science components.
- Utilization in combinatorial chemistry libraries for drug discovery programs.
Quality Assurance and Advantages
As a dedicated global manufacturer, we prioritize product integrity and supply chain reliability. Each production lot undergoes comprehensive analytical testing using state-of-the-art instrumentation, including GC, HPLC, and NMR spectroscopy. We provide a detailed Certificate of Analysis (COA) with every shipment to verify compliance with stated specifications. Our commitment to industrial purity ensures minimal impurities that could interfere with downstream synthesis processes.
Choosing our supply partner means gaining access to competitive bulk pricing, scalable production capacity, and expert technical support. We understand the critical nature of timely delivery in research and development cycles and strive to maintain optimal inventory levels to meet urgent procurement requirements.
Storage and Handling
To maintain stability and safety, 4-Bromo-2-fluoropyridine should be stored in a tightly closed container within a cool, dry, and well-ventilated area. It is essential to protect the material from moisture and direct sunlight. Personnel handling this chemical must adhere to standard safety protocols, including the use of appropriate personal protective equipment such as gloves and safety goggles. In case of spills, follow established hazardous material containment procedures to ensure workplace safety and environmental compliance.
