4-Bromo-2-Fluorotoluene
- CAS No.51436-99-8
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High purity 4-Bromo-2-Fluorotoluene (CAS 51436-99-8) designed for pharmaceutical and agrochemical synthesis. Available in bulk quantities with comprehensive quality documentation.
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Product Overview
4-Bromo-2-Fluorotoluene is a specialized fluorinated aromatic intermediate that plays a critical role in modern organic synthesis. Characterized by its unique substitution pattern featuring both bromine and fluorine atoms on a toluene backbone, this compound serves as a versatile building block for complex molecular construction. Our manufacturing process ensures consistent quality and high purity levels suitable for demanding research and industrial applications.
The presence of the bromine substituent provides an excellent handle for palladium-catalyzed cross-coupling reactions, including Suzuki-Miyaura and Buchwald-Hartwig aminations. Meanwhile, the fluorine atom imparts beneficial electronic properties and enhances metabolic stability in final pharmaceutical products. This dual functionality makes the material indispensable for medicinal chemistry programs focused on developing next-generation therapeutics.
Technical Specifications
| Parameter | Specification |
|---|---|
| CAS Number | 51436-99-8 |
| Molecular Formula | C7H6BrF |
| Molecular Weight | 189.03 g/mol |
| Appearance | Colorless to light yellow transparent liquid |
| Purity | ≥98.0% |
| Water Content | ≤0.5% |
| Density | 1.492 g/mL at 25 °C |
| Boiling Point | 68 °C at 8 mmHg |
| Refractive Index | n20/D 1.529 |
Industrial Applications
This fluorinated intermediate is extensively utilized across multiple high-value sectors. In the pharmaceutical industry, it acts as a key precursor for synthesizing kinase inhibitors and other small molecule drugs where fluorine substitution is crucial for bioavailability. Agrochemical manufacturers leverage this compound to develop advanced herbicides and pesticides with improved environmental profiles.
- Pharmaceutical intermediate for drug discovery
- Agrochemical synthesis for crop protection agents
- Organic synthesis building block for fine chemicals
- Material science applications requiring fluorinated aromatics
Quality Assurance And Storage
We maintain rigorous quality control protocols throughout the production cycle. Each batch undergoes comprehensive analysis using gas chromatography and other advanced techniques to verify purity and identity. A Certificate of Analysis (COA) is provided with every shipment to ensure full traceability and compliance with international standards.
Proper storage is essential to maintain product integrity. The material should be kept in a cool, dry, and well-ventilated area away from incompatible substances. Containers must remain tightly closed when not in use to prevent moisture absorption and contamination. We offer flexible packaging options including 25kg drums to accommodate various production scales and logistical requirements.
