4-Bromo-3-fluoroanisole
- CAS No.458-50-4
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 4-Bromo-3-fluoroanisole (CAS 458-50-4) designed for advanced organic synthesis and pharmaceutical intermediate applications with guaranteed quality.
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Product Overview
4-Bromo-3-fluoroanisole is a sophisticated halogenated aromatic intermediate extensively utilized in modern organic synthesis and pharmaceutical development. Characterized by its unique substitution pattern featuring both bromine and fluorine atoms on an anisole backbone, this compound serves as a critical building block for constructing complex molecular architectures. Our manufacturing process ensures high chemical purity and consistency, making it an ideal choice for research and industrial scale applications where reliability is paramount.
The presence of the bromine atom facilitates various palladium-catalyzed cross-coupling reactions, such as Suzuki-Miyaura or Buchwald-Hartwig aminations, while the fluorine substituent enhances metabolic stability and lipophilicity in final drug candidates. This dual functionality makes 4-Bromo-3-fluoroanisole a versatile reagent in medicinal chemistry pipelines, enabling chemists to explore diverse chemical spaces efficiently.
Technical Specifications
| Parameter | Value |
|---|---|
| CAS Number | 458-50-4 |
| Molecular Formula | C7H6BrFO |
| Molecular Weight | 205.02 g/mol |
| Appearance | Colorless liquid |
| Purity | ≥99.0% |
| Density | 1.531 g/cm3 |
| Boiling Point | 195.4°C at 760 mmHg |
| Melting Point | 217-219°C |
| Flash Point | 85.4°C |
| Refractive Index | 1.518 |
Industrial Applications
This chemical intermediate is primarily employed in the synthesis of active pharmaceutical ingredients and agrochemical compounds. Its specific reactivity profile allows chemists to introduce functional groups selectively, enabling the development of novel therapeutics and advanced materials. The compound is particularly valuable in the creation of kinase inhibitors and other targeted therapies where precise structural modification is required.
- Pharmaceutical intermediate for kinase inhibitors and targeted therapies.
- Essential building block for fluorinated aromatic compounds.
- Key reagent in palladium-catalyzed cross-coupling reactions.
- Material science research applications for polymer development.
- Agrochemical synthesis for next-generation crop protection agents.
Quality Assurance and Storage
To maintain optimal quality, store this product in a tightly closed container within a cool, dry, and well-ventilated area. Ensure separation from incompatible substances such as strong oxidizing agents to prevent hazardous reactions. Always adhere to standard safety protocols and consult the safety data sheet before handling any chemical materials in the laboratory or production facility.
We commit to delivering premium quality chemicals with comprehensive documentation, including Certificates of Analysis, to support your regulatory compliance and quality assurance needs. Our global supply chain ensures timely delivery and consistent batch-to-batch quality, supporting your production schedules without interruption. Contact our technical team for detailed specifications and bulk pricing options tailored to your specific project requirements.
