4-Bromo-3-fluorobenzaldehyde

Product Overview

4-Bromo-3-fluorobenzaldehyde represents a critical fluorinated aromatic building block extensively utilized in modern organic synthesis and industrial chemistry. As a key intermediate, this compound facilitates the construction of complex molecular architectures required in pharmaceutical and agrochemical development. Our facility produces this material under strict quality control standards to ensure consistency and reliability for large-scale industrial applications. The presence of both bromine and fluorine substituents on the benzene ring provides unique reactivity profiles, enabling diverse chemical transformations such as cross-coupling reactions and nucleophilic substitutions. This dual halogenation strategy is highly valued in medicinal chemistry for optimizing drug candidates.

Chemical Properties

This compound typically presents as a white to light yellow solid at room temperature, exhibiting high stability under standard storage conditions. The molecular formula C7H4BrFO corresponds to a molecular weight of approximately 203.01 g/mol. Key physical properties include a density of 1.67 g/cm3 and a boiling point around 240.2 degrees Celsius. The flash point is recorded at 137 degrees Celsius, indicating specific handling requirements for safety compliance. The refractive index is measured at 1.584, which serves as a key identifier for purity verification during quality assurance testing. These physical constants are essential for process engineers designing synthesis routes involving this aldehyde functionality.

Industrial Applications

The primary application lies in the synthesis of advanced pharmaceutical active ingredients where fluorine incorporation enhances metabolic stability and bioavailability. It serves as a versatile precursor for producing kinase inhibitors and other therapeutic agents targeting neurological pathways. In agrochemicals, it contributes to the development of herbicides and pesticides with improved environmental profiles and efficacy. Additionally, material science researchers utilize this building block for creating specialized polymers and liquid crystals. The dual halogen substitution allows for selective functionalization, making it superior to mono-substituted analogues in multi-step synthesis sequences. The aldehyde group provides a reactive handle for further derivatization into acids, alcohols, or imines.

Specifications

We maintain rigorous testing protocols to guarantee product quality across all production batches. Each lot undergoes comprehensive analysis using high-performance liquid chromatography to confirm purity levels meet international standards. The standard specification requires a minimum purity of 99.0 percent, ensuring minimal impurity interference in downstream reactions. Certificates of analysis are provided with every shipment to document compliance with internal and external quality standards. Our manufacturing process is optimized to reduce heavy metal residues and organic volatile impurities to negligible levels. Customers can request additional testing parameters based on specific project requirements.

Storage and Handling

Proper storage is vital to maintain chemical integrity over extended periods. The product should be stored in a cool, ventilated place away from direct sunlight and moisture sources to prevent degradation. Containers must remain tightly sealed when not in use to prevent oxidation or hydrolysis of the aldehyde group. We recommend using standard personal protective equipment during handling, including gloves and safety goggles, to ensure operator safety. Packaging options include 25 kg drums, with customization available to meet specific logistical requirements for global shipping. Our global supply chain ensures timely delivery while maintaining product stability during transit through controlled temperature logistics.