Intermediates

4-Bromo-3-fluorobenzoic acid

  • CAS No.153556-42-4
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 4-Bromo-3-fluorobenzoic acid (CAS 153556-42-4) designed for advanced organic synthesis. Reliable supply for pharmaceutical and agrochemical intermediate production.

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Product Technical Details

Product Overview

4-Bromo-3-fluorobenzoic acid represents a critical halogenated building block within the realm of advanced organic synthesis. As a specialized aromatic carboxylic acid derivative, this compound features both bromine and fluorine substituents on the benzene ring, offering unique reactivity profiles essential for modern medicinal chemistry and material science applications. Our manufacturing process ensures consistent quality and high purity levels, making it an ideal choice for researchers and industrial producers alike.

This compound serves as a versatile precursor in the construction of complex molecular architectures. The presence of the bromine atom facilitates various cross-coupling reactions, such as Suzuki-Miyaura or Buchwald-Hartwig couplings, while the fluorine substituent can significantly influence the metabolic stability and lipophilicity of the final pharmaceutical agents. We are committed to supplying this key intermediate with rigorous quality control standards to support your development pipelines.

Key Features and Advantages

  • High Chemical Purity: Manufactured to meet or exceed 99.0% purity specifications via HPLC analysis.
  • Consistent Quality: Batch-to-batch consistency ensured through strict quality assurance protocols.
  • Versatile Reactivity: Suitable for a wide range of coupling and substitution reactions.
  • Global Supply Chain: Reliable logistics network capable of handling bulk orders worldwide.
  • Technical Support: Dedicated team available to assist with application-specific queries.

Technical Specifications

ParameterSpecification
Chemical Name4-Bromo-3-fluorobenzoic acid
CAS Number153556-42-4
Molecular FormulaC7H4BrFO2
Molecular Weight219.01 g/mol
AppearanceWhite to light yellow powder
Purity (HPLC)≥99.0%
Melting Point209-212°C
Density1.34 g/cm³

Industrial Applications

Primarily utilized as an intermediate in organic synthesis, this fluorinated benzoic acid derivative finds extensive application in the pharmaceutical industry. It is frequently employed in the synthesis of kinase inhibitors, receptor modulators, and other biologically active compounds where halogen substitution is required to optimize binding affinity. Additionally, it serves as a valuable building block in agrochemical development, contributing to the creation of novel herbicides and pesticides with improved environmental profiles.

Beyond life sciences, the compound is applicable in material science for the development of specialized polymers and liquid crystals. The dual halogen substitution allows for precise functionalization, enabling chemists to tailor material properties such as thermal stability and electronic characteristics. Our production capabilities support both small-scale research quantities and large-scale industrial demands.

Storage and Packaging

To maintain optimal stability and purity, 4-Bromo-3-fluorobenzoic acid should be stored in a cool, ventilated area away from direct sunlight and moisture. The standard packaging configuration is 25 kg per drum, ensuring safe transport and handling. However, we understand that diverse projects require flexible solutions. Therefore, we offer custom packaging options according to specific customer requirements. All shipments are accompanied by a Certificate of Analysis (COA) to verify compliance with stated specifications.