Intermediates

4-Bromo-3-fluorotoluene

  • CAS No.452-74-4
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High purity 4-Bromo-3-fluorotoluene (CAS 452-74-4) designed for advanced organic synthesis and pharmaceutical intermediate applications.

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Product Technical Details

Product Overview

4-Bromo-3-fluorotoluene is a highly valued fluorinated aromatic compound widely utilized in modern chemical synthesis. As a key building block, this substance plays a critical role in the construction of complex molecular structures required for pharmaceutical and agrochemical development. Our facility produces this intermediate under strict quality control standards to ensure consistent performance in downstream reactions. The presence of both bromine and fluorine substituents on the toluene backbone provides unique reactivity profiles, making it an essential reagent for cross-coupling reactions and nucleophilic substitutions.

We understand the importance of reliability in the supply chain for research and production teams. Therefore, every batch undergoes rigorous analytical testing to verify identity and purity levels. This commitment to quality ensures that chemists can rely on our materials for reproducible results in their synthetic pathways.

Technical Specifications

The following table outlines the key physical and chemical properties of our standard grade product. These parameters are verified using advanced instrumentation including gas chromatography and refractive index analysis.

ParameterSpecification
Product Name4-Bromo-3-fluorotoluene
CAS Number452-74-4
Molecular FormulaC7H6BrF
Molecular Weight189.02 g/mol
AppearanceColorless to light yellow transparent liquid
Purity≥98.0%
Water Content≤0.5%
Density1.494 g/mL at 25 °C
Boiling Point95 °C at 50 mm Hg
Refractive Indexn20/D 1.53

Industrial Applications

This fluorinated intermediate serves as a versatile precursor in multiple industries. In the pharmaceutical sector, it is frequently employed in the synthesis of active pharmaceutical ingredients (APIs). The introduction of fluorine atoms into drug molecules is a common strategy to enhance metabolic stability and bioavailability. Consequently, this compound is utilized in the research and development of novel therapeutic agents, including projects focused on oncology and other specialized medical fields.

Beyond pharmaceuticals, 4-Bromo-3-fluorotoluene is applicable in agrochemical synthesis where fluorinated structures often exhibit improved pesticidal activity. Organic chemists also value this material for its utility in palladium-catalyzed coupling reactions such as Suzuki or Buchwald-Hartwig couplings. The specific substitution pattern allows for selective functionalization, enabling the efficient construction of biaryl systems and other complex architectures.

  • Pharmaceutical intermediate synthesis
  • Agrochemical research and development
  • Organic synthesis building block
  • Fluorinated compound manufacturing

Quality Assurance and Safety

Quality is paramount in our manufacturing process. We implement a comprehensive quality management system that covers raw material inspection, in-process control, and final product verification. Certificates of Analysis (COA) are provided with every shipment to document compliance with specified standards. Our laboratory is equipped to handle detailed impurity profiling, ensuring that trace contaminants are kept within acceptable limits for sensitive synthetic applications.

Regarding safety and handling, this product is classified as a flammable liquid. It should be stored in a cool, dry, and well-ventilated area away from incompatible materials such as strong oxidizing agents. Containers must remain tightly closed when not in use to prevent moisture absorption and vapor release. Personnel handling this chemical should wear appropriate personal protective equipment including gloves and safety goggles. We adhere to international shipping regulations, ensuring safe transport via approved logistics partners globally.