4-Bromo-3-nitrobenzotrifluoride
- CAS No.349-03-1
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High purity 4-Bromo-3-nitrobenzotrifluoride (CAS 349-03-1) designed for advanced organic synthesis and pharmaceutical intermediate applications.
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Product Overview
4-Bromo-3-nitrobenzotrifluoride is a highly specialized fluorinated aromatic intermediate designed for complex organic synthesis applications. This compound features a unique structural arrangement with a bromine atom, a nitro group, and a trifluoromethyl group attached to the benzene ring. Such multifunctionality makes it an invaluable building block for medicinal chemistry and agrochemical research. Our manufacturing process ensures high consistency and reliability for large-scale industrial use.
The introduction of the trifluoromethyl group significantly enhances the lipophilicity and metabolic stability of downstream molecules. This property is crucial in the development of modern pharmaceuticals where bioavailability is a key parameter. The bromine and nitro functionalities offer versatile sites for further chemical transformations, including nucleophilic aromatic substitution and palladium-catalyzed cross-coupling reactions. The electron-withdrawing nature of the nitro and trifluoromethyl groups activates the aromatic ring for specific substitution patterns.
Technical Specifications
| Parameter | Value |
|---|---|
| CAS Number | 349-03-1 |
| Molecular Formula | C7H3BrF3NO2 |
| Molecular Weight | 270.00 g/mol |
| Appearance | Yellow liquid |
| Purity | ≥98.0% |
| Boiling Point | 90 °C (3 mmHg) |
| Density | 1.763 g/cm3 |
| Flash Point | >230 °F |
Industrial Applications
This chemical serves as a critical precursor in the synthesis of advanced functional materials. It is extensively used in the preparation of kinase inhibitors and other therapeutic agents where fluorine substitution is required to modulate electronic properties. Additionally, it finds application in the agrochemical sector for developing novel pesticides with improved environmental profiles. The versatility of this intermediate allows chemists to design diverse molecular architectures efficiently.
- Ideal for nucleophilic substitution reactions due to the activated nitro group.
- Suitable for cross-coupling reactions leveraging the bromo substituent.
- Enhances metabolic stability in final pharmaceutical products.
- Used in material science for creating high-performance polymers.
- Supports research in novel fluorinated compound development.
Quality Assurance and Storage
We adhere to strict quality control protocols to ensure every batch meets the specified purity levels. Each shipment is accompanied by a Certificate of Analysis (COA) verifying physical and chemical properties. Proper storage is essential to maintain product integrity. Store in a tightly closed container in a cool, dry environment away from incompatible materials. We offer flexible packaging options to meet specific customer requirements, ensuring safe transport globally.
Our commitment to safety and compliance means all products are handled according to international regulatory standards. Handling requires appropriate personal protective equipment including gloves and eye protection. Adequate ventilation should be maintained during use. For technical inquiries or custom synthesis requests, our expert team is available to provide comprehensive support throughout your project lifecycle. We ensure stable supply chains to support your production schedules without interruption.
