Intermediates

4-Bromobenzo[b]thiophene

  • CAS No.5118-13-8
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 4-Bromobenzo[b]thiophene (CAS 5118-13-8) supplied for pharmaceutical synthesis. Ideal intermediate for advanced therapeutic manufacturing with strict quality control.

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Product Technical Details

Product Overview

4-Bromobenzo[b]thiophene is a highly specialized heterocyclic compound that serves as a critical building block in modern medicinal chemistry. Characterized by its brominated thiophene structure, this chemical intermediate plays a pivotal role in the synthesis of complex pharmaceutical agents. Our facility produces this compound under strict quality management systems to ensure consistency and reliability for downstream manufacturing processes. The molecule features a benzo[b]thiophene core substituted with a bromine atom at the fourth position, providing a reactive site for various cross-coupling reactions essential in drug discovery and development.

As a leading global manufacturer, we understand the stringent requirements of the pharmaceutical industry. Therefore, our production process emphasizes high purity and minimal impurity profiles. This ensures that chemists and process engineers can rely on our material for sensitive synthetic routes without compromising the quality of the final active pharmaceutical ingredients. The stability and reactivity of this brominated derivative make it an indispensable tool for constructing diverse molecular architectures required in next-generation therapeutics.

Technical Specifications

To guarantee performance in your synthesis workflows, we adhere to rigorous analytical standards. Each batch undergoes comprehensive testing using advanced chromatography and spectroscopy methods. The following table outlines the key physical and chemical parameters that define our standard grade material:

ParameterSpecification
Chemical Name4-Bromobenzo[b]thiophene
CAS Number5118-13-8
Molecular FormulaC8H5BrS
Molecular Weight213.09 g/mol
AppearanceOff-white Solid
Purity≥99.0%
Water Content<0.5%
Density1.649 g/cm3
Boiling Point284.7ºC at 760mmHg
Flash Point126ºC

These specifications are designed to meet the demands of large-scale industrial applications while maintaining the flexibility required for laboratory-scale research. Our quality control team verifies every parameter before release, ensuring that the material performs predictably in your specific reaction conditions. We provide full documentation including Certificates of Analysis for every shipment.

Industrial Applications

This intermediate is primarily utilized in the pharmaceutical sector for the synthesis of advanced therapeutic compounds. It serves as a key precursor in the manufacturing of antipsychotic medications and other neurological therapeutics. Specifically, it is known for its utility in the production pipeline of complex APIs requiring heterocyclic scaffolds, such as Brexpiprazole. The bromine functionality allows for versatile coupling reactions, such as Suzuki or Stille couplings, enabling chemists to introduce diverse functional groups efficiently.

Beyond pharmaceuticals, this compound may find applications in agrochemical research and material science where sulfur-containing heterocycles are required. Our commitment to supply chain stability means that clients can secure long-term contracts for continuous production runs, mitigating the risk of project delays due to material shortages. We support custom synthesis projects to meet unique molecular requirements.

Storage and Handling

Proper storage is essential to maintain the integrity of 4-Bromobenzo[b]thiophene. The material should be kept in tightly closed containers to prevent exposure to moisture and air. We recommend storing the product in a cool, dry, and well-ventilated area away from incompatible substances such as strong oxidizing agents. Standard industrial safety protocols should be followed during handling, including the use of appropriate personal protective equipment. Our packaging options include 25kg cardboard drums, customized according to customer-specific logistical requirements to ensure safe global transit and compliance with international shipping regulations.