4-Bromobenzotrifluoride
- CAS No.402-43-7
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 4-Bromobenzotrifluoride (CAS 402-43-7) is a vital fluorinated intermediate for pharmaceutical synthesis, available in bulk quantities with strict quality control.
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Product Overview
4-Bromobenzotrifluoride is a highly valued organofluorine compound widely utilized in the fine chemical and pharmaceutical industries. Characterized by a benzene ring substituted with both a bromine atom and a trifluoromethyl group at the para positions, this chemical serves as a critical building block for complex molecular architectures. Our facility specializes in the production of this intermediate, ensuring consistent quality and supply chain reliability for global partners engaged in advanced organic synthesis.
The introduction of the trifluoromethyl group into organic molecules is a strategic move in medicinal chemistry, often enhancing metabolic stability, lipophilicity, and bioavailability of the final active pharmaceutical ingredients. When combined with the reactive bromine site, this molecule offers versatile opportunities for cross-coupling reactions, making it indispensable for modern drug discovery and development processes.
Key Specifications
| Parameter | Value |
|---|---|
| Chemical Name | 4-Bromobenzotrifluoride |
| CAS Number | 402-43-7 |
| Molecular Formula | C7H4BrF3 |
| Molecular Weight | 225.01 g/mol |
| Appearance | Clear Liquid |
| Purity | ≥99.0% |
| Boiling Point | 154-155 °C |
| Density | 1.607 g/cm3 |
| Refractive Index | 1.472 |
Industrial Applications
As a premier intermediate, this compound finds extensive application in the synthesis of pharmaceuticals, agrochemicals, and functional materials. The bromine functionality allows for palladium-catalyzed coupling reactions such as Suzuki, Heck, and Sonogashira couplings, facilitating the construction of biaryl structures common in many therapeutic agents. Furthermore, the stability of the carbon-fluorine bonds ensures that the trifluoromethyl moiety remains intact throughout harsh synthetic conditions.
- Pharmaceutical Intermediates: Used in the production of various APIs requiring fluorinated aromatic structures.
- Agrochemical Synthesis: Serves as a precursor for herbicides and pesticides with enhanced environmental stability.
- Organic Electronics: Utilized in the development of specialized materials requiring specific electronic properties.
- Custom Synthesis: Available for tailored research and development projects requiring high-grade starting materials.
Quality Assurance and Storage
We adhere to strict quality management systems to guarantee that every batch of 4-Bromobenzotrifluoride meets or exceeds industry standards. Each shipment is accompanied by a comprehensive Certificate of Analysis (COA), detailing purity levels and physical properties verified through advanced analytical techniques such as GC and HPLC. Our commitment to industrial purity ensures minimal impurities that could interfere with downstream reactions.
For optimal preservation, the product should be stored in a tightly closed container within a cool, dry, and well-ventilated area. It is essential to protect the material from moisture and direct sunlight to maintain its chemical integrity over time. Our packaging solutions are designed to meet customer-specific requirements, ensuring safe transit and handling across international borders. Partner with us for reliable bulk supply and expert technical support in fluorinated chemistry.
