Intermediates

4-Bromochlorobenzene

  • CAS No.106-39-8
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 4-Bromochlorobenzene (CAS 106-39-8) designed for advanced organic synthesis. Reliable supply with strict quality control for pharmaceutical and agrochemical intermediates.

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Product Technical Details

Product Overview

4-Bromochlorobenzene is a premier halogenated aromatic compound extensively utilized in modern organic synthesis and industrial chemistry. As a key building block, this substance features a benzene ring substituted with both bromine and chlorine atoms at para positions, offering unique reactivity profiles for complex molecular construction. Our manufacturing facility produces this intermediate under strict quality assurance protocols to ensure consistency for downstream applications in pharmaceuticals, agrochemicals, and advanced material science.

The compound serves as a critical precursor in cross-coupling reactions, including Suzuki and Grignard processes, where the differential reactivity of the halogen atoms allows for selective functionalization. This selectivity makes it an invaluable asset for chemists designing multi-step synthesis routes for active pharmaceutical ingredients (APIs) and specialized organic molecules.

Key Physical and Chemical Properties

Understanding the physical characteristics of 4-Bromochlorobenzene is essential for safe handling and effective integration into synthesis workflows. The substance typically presents as a crystalline solid at room temperature, exhibiting high stability under standard storage conditions. Its density and refractive index are consistent with high-grade halogenated benzenes, facilitating easy identification and quality verification during incoming inspection.

Thermal properties such as melting and boiling points are tightly controlled during production. The high flash point indicates favorable safety characteristics compared to more volatile solvents, though standard precautions for halogenated organic compounds must always be observed. The molecular structure provides a balanced platform for further chemical modification, supporting both nucleophilic and electrophilic substitution strategies depending on the specific reaction conditions employed.

Technical Specifications

ParameterSpecification
Chemical Name4-Bromochlorobenzene
CAS Number106-39-8
Molecular FormulaC6H4BrCl
Molecular Weight191.45 g/mol
AppearanceColorless needle or flaky crystal
Purity (GC)≥98.5%
Moisture Content≤0.1%
Residue on Ignition≤0.01%
Density1.651 g/cm3
Melting Point64-67oC
Boiling Point196oC

Industrial Applications

The primary utility of 4-Bromochlorobenzene lies in its role as a versatile intermediate. In the pharmaceutical sector, it is employed to construct biaryl structures common in many therapeutic agents. The presence of two different halogens allows chemists to exploit orthogonal reactivity, enabling sequential coupling reactions that build molecular complexity efficiently. This capability reduces the number of synthesis steps required, improving overall yield and cost-effectiveness for large-scale production.

In agrochemical development, this compound contributes to the synthesis of herbicides and fungicides where aromatic halogenation enhances biological activity and environmental stability. Additionally, it finds use in the production of liquid crystals and organic electronic materials, where precise molecular geometry is paramount. Our global manufacturing network ensures that supply chains remain robust, supporting continuous research and production activities worldwide.

Quality Assurance and Packaging

Quality is the cornerstone of our chemical supply service. Every batch of 4-Bromochlorobenzene undergoes rigorous testing using gas chromatography and other analytical methods to verify purity levels meet or exceed the 98.5% threshold. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Moisture content and residue levels are minimized to prevent interference with sensitive catalytic reactions.

Standard packaging consists of 25 kg drums designed to protect the product from moisture and physical damage during transit. Custom packaging solutions are available to meet specific logistical requirements. Storage recommendations include keeping the material in a cool, ventilated area away from incompatible substances. Our commitment to safety and quality makes us a trusted partner for laboratories and industrial facilities seeking reliable chemical intermediates.