Intermediates

4-(Bromomethyl)phenylboronic Acid

  • CAS No.68162-47-0
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 4-(Bromomethyl)phenylboronic Acid (CAS 68162-47-0) designed for advanced pharmaceutical synthesis and cross-coupling reactions.

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Product Technical Details

Product Overview

4-(Bromomethyl)phenylboronic Acid represents a sophisticated class of organoboron compounds designed for advanced organic synthesis. This molecule features a phenyl ring substituted with both a boronic acid group and a bromomethyl group at the para position. This specific arrangement provides chemists with a powerful tool for multi-step synthesis, allowing for sequential functionalization strategies that are essential in modern medicinal chemistry and material science. Our production process focuses on maximizing yield while maintaining stringent purity levels to minimize side reactions in downstream applications.

The stability of the boronic acid group under various conditions makes this compound a reliable choice for complex synthesis pathways. Unlike some sensitive reagents, this product offers a balanced reactivity profile that allows for controlled transformations. The high purity specification of ≥98.0% ensures that impurities do not interfere with catalytic cycles, which is critical when working with precious metal catalysts commonly used in cross-coupling reactions. We understand that consistency is key for industrial scale-up, and our manufacturing processes are optimized to deliver batch-to-batch reproducibility.

Technical Specifications

Parameter Value
Product Name 4-(Bromomethyl)phenylboronic Acid
CAS Number 68162-47-0
Molecular Formula C7H8BBrO2
Molecular Weight 214.85 g/mol
Appearance White Powder
Assay ≥98.0%
Water Content ≤0.50%
Melting Point 78-81°C
Boiling Point 343.1°C at 760 mmHg
Density 1.57 g/cm3
Flash Point 161.3°C

Industrial Applications

This chemical serves as a critical intermediate in the pharmaceutical and agrochemical sectors. Its primary application lies in Suzuki-Miyaura cross-coupling reactions, where it acts as a nucleophilic partner to couple with aryl or vinyl halides. This reaction is fundamental in constructing biaryl structures found in numerous active pharmaceutical ingredients. Furthermore, the bromomethyl functionality enables alkylation reactions, expanding its utility in synthesizing heterocycles and biologically active compounds. The dual reactive sites allow for divergent synthesis, enabling researchers to explore chemical space more efficiently.

Beyond pharmaceuticals, this building block is utilized in the development of functional materials, including polymers and organic electronic components. The ability to introduce boron functionality into a molecular framework opens doors to further derivatization via oxidation or halogenation. Industries relying on precise chemical structures benefit from the high assay and low water content provided in our standard grades. This ensures that reaction kinetics remain predictable and that purification steps downstream are minimized, saving both time and resources in the production lifecycle.

Quality Assurance and Storage

  • Manufactured in compliance with international quality standards and safety regulations.
  • Each batch is accompanied by a comprehensive Certificate of Analysis (COA).
  • Packaged in 25kg drums or customized according to specific client requirements.
  • Store in a cool, dry, and well-ventilated area away from direct moisture.
  • Keep containers tightly closed to prevent hydrolysis or degradation.
  • Non-dangerous goods classification facilitates easier transport and handling.

We are committed to providing reliable supply chains for essential chemical building blocks. Our logistics team ensures safe and timely delivery globally, adhering to all transport regulations. For specific technical data or custom synthesis requirements, our support team is available to assist with detailed documentation and regulatory compliance information. Partnering with us means accessing a robust inventory and expert technical support to streamline your procurement process.