Intermediates

(4-Butoxy-2,3-difluorophenyl)boronic acid

  • CAS No.156487-12-6
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity (4-Butoxy-2,3-difluorophenyl)boronic acid designed for pharmaceutical and OLED intermediate synthesis with guaranteed assay specifications.

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Product Technical Details

Product Overview

(4-Butoxy-2,3-difluorophenyl)boronic acid represents a sophisticated arylboronic acid derivative engineered for high-performance organic synthesis. This compound serves as a critical building block in the construction of complex molecular architectures, particularly within the pharmaceutical and advanced materials sectors. The presence of the butoxy group alongside the difluoro substitution pattern on the phenyl ring imparts unique electronic and steric properties, making it an indispensable reagent for cross-coupling reactions. Our manufacturing process ensures exceptional batch-to-batch consistency, catering to the rigorous demands of industrial research and development teams seeking reliable chemical solutions.

As a specialized fine chemical, this boronic acid derivative is synthesized under strictly controlled conditions to minimize impurities and maximize yield. The molecular structure allows for versatile functionalization, enabling chemists to introduce specific substituents into target molecules with high precision. Whether utilized in medicinal chemistry programs or material science applications, this product delivers the performance required for modern synthetic challenges.

Technical Specifications

ParameterValue
CAS Number156487-12-6
Molecular FormulaC10H13BF2O3
Molecular Weight230.02 g/mol
AppearanceWhite powder
Assay (Purity)≥98.0%
Water Content≤0.50%
Density1.2±0.1 g/cm3
Boiling Point341.7±52.0 °C at 760 mmHg
Flash Point160.4±30.7 °C
UN NumberUN3261
Hazard Class8

Industrial Applications

Primarily utilized as a key intermediate in the synthesis of active pharmaceutical ingredients (APIs), this boronic acid facilitates efficient Suzuki-Miyaura coupling reactions. The fluorine atoms enhance metabolic stability in drug candidates, while the butoxy chain offers solubility modulation. Beyond pharmaceuticals, it finds significant application in the production of organic light-emitting diode (OLED) materials, where precise electronic characteristics are paramount. Researchers value this compound for its reliability in forming carbon-carbon bonds under palladium catalysis.

  • Pharmaceutical intermediate synthesis for novel drug discovery
  • OLED material production requiring specific electronic properties
  • Advanced organic synthesis involving cross-coupling methodologies
  • Chemical biology probe development

Quality Assurance and Safety

Each batch undergoes rigorous testing using high-performance liquid chromatography (HPLC) and nuclear magnetic resonance (NMR) spectroscopy to verify identity and purity. We maintain a robust quality management system to ensure that every shipment meets the specified assay requirements. Proper handling is essential to maintain the integrity of this chemical. Store in a cool, dry, and well-ventilated area away from incompatible substances. The container must remain tightly closed to prevent moisture absorption, which can lead to anhydride formation. Transport classification adheres to international safety standards, ensuring secure global logistics. We provide comprehensive safety data sheets and certificates of analysis with every shipment to guarantee compliance with your local regulatory requirements.

Packaging and Storage

Standard packaging consists of 25kg drums, designed to protect the product during transit and storage. Custom packaging solutions are available according to customer requirements to facilitate integration into your supply chain. For optimal stability, store in a cool place and keep the container tightly closed in a dry and well-ventilated environment. Our logistics team ensures timely delivery while maintaining all necessary safety protocols for hazardous materials transport.