(4-Chloro-3,5-difluorophenyl)boronic acid
- CAS No.864759-63-7
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
Premium grade (4-Chloro-3,5-difluorophenyl)boronic acid designed for complex pharmaceutical synthesis and Suzuki coupling reactions.
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Product Overview
(4-Chloro-3,5-difluorophenyl)boronic acid is a highly specialized arylboronic acid derivative engineered for advanced organic synthesis applications. As a critical building block in medicinal chemistry, this compound features a unique substitution pattern with both chloro and difluoro groups on the phenyl ring, offering distinct reactivity profiles for cross-coupling reactions. Our manufacturing process ensures exceptional batch-to-batch consistency, making it an ideal choice for research and development teams focused on creating novel pharmaceutical candidates.
This chemical serves as a versatile intermediate in the construction of biaryl structures, which are prevalent in many modern drug molecules. The presence of fluorine atoms enhances metabolic stability and lipophilicity, while the chloro group provides a handle for further functionalization. We supply this material under strict quality control standards to support efficient scale-up from laboratory discovery to commercial production.
Chemical Specifications
| Parameter | Specification |
|---|---|
| Product Name | (4-Chloro-3,5-difluorophenyl)boronic acid |
| CAS Number | 864759-63-7 |
| Molecular Formula | C6H4BClF2O2 |
| Molecular Weight | 192.36 g/mol |
| Appearance | White powder |
| Assay (Purity) | ≥98.0% |
| Water Content | ≤0.50% |
| Density | 1.503 g/cm3 |
| Boiling Point | 301.2°C at 760 mmHg |
Industrial Applications
The primary utility of (4-Chloro-3,5-difluorophenyl)boronic acid lies in its role as a coupling partner in palladium-catalyzed Suzuki-Miyaura reactions. This transformation is fundamental in the synthesis of complex organic frameworks required for active pharmaceutical ingredients (APIs). The compound's stability under standard storage conditions allows for reliable inventory management in large-scale manufacturing facilities.
- Pharmaceutical Intermediate: Used extensively in the synthesis of kinase inhibitors and other targeted therapies.
- Agrochemical Synthesis: Employed in the development of advanced crop protection agents requiring fluorinated motifs.
- Material Science: Utilized in the creation of specialized organic electronic materials and polymers.
- Research Reagent: Serves as a standard reference compound for method development in organic chemistry laboratories.
Quality Assurance and Storage
Quality is paramount in our production facility. Each batch of (4-Chloro-3,5-difluorophenyl)boronic acid undergoes rigorous analytical testing, including HPLC, NMR, and Karl Fischer titration, to verify purity and identity. We provide a comprehensive Certificate of Analysis (COA) with every shipment to ensure compliance with your internal quality standards.
For optimal stability, this product should be stored in a cool, dry, and well-ventilated area. Keep the container tightly closed to prevent moisture absorption, which can lead to the formation of boronic acid anhydrides. Proper handling procedures should be followed according to standard safety guidelines for fine chemicals. We offer flexible packaging options, including 25kg drums, customized to meet specific logistical requirements for global distribution.
