4-Chloro-3-fluoroaniline
- CAS No.367-22-6
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
4-Chloro-3-fluoroaniline is a high-purity pharmaceutical intermediate essential for synthesizing kinase inhibitors and antiretroviral compounds.
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Product Overview
4-Chloro-3-fluoroaniline represents a critical halogenated aromatic amine utilized extensively within the fine chemical and pharmaceutical industries. As a specialized building block, this compound features a unique substitution pattern on the benzene ring, incorporating both chlorine and fluorine atoms. This specific structural configuration enhances its reactivity and suitability for complex organic synthesis pathways. Our facility produces this material under strict quality control protocols to ensure consistency across batches, meeting the rigorous demands of modern medicinal chemistry research and development.
The presence of halogen substituents significantly influences the electronic properties of the aniline core, making it an ideal precursor for constructing heterocyclic systems. These systems are foundational in the development of advanced therapeutic agents. We prioritize safety and purity in every production run, providing comprehensive documentation to support regulatory compliance for our global partners.
Technical Specifications
Our manufacturing process ensures that 4-Chloro-3-fluoroaniline meets high industry standards for purity and physical characteristics. The following table outlines the key technical parameters verified through our quality assurance laboratory.
| Parameter | Specification |
|---|---|
| CAS Number | 367-22-6 |
| Molecular Formula | C6H5ClFN |
| Molecular Weight | 145.56 g/mol |
| Appearance | White crystalline powder |
| Purity | ≥99.0% |
| Melting Point | 61°C |
| Boiling Point | 234.7°C at 760 mmHg |
| Density | 1.349 g/cm3 |
| Refractive Index | 1.570 |
Industrial Applications
This fluorinated aniline derivative serves as a vital intermediate in the synthesis of complex pharmaceutical active ingredients. It is specifically employed in the production of Methyl 5-Chloro-4-fluoro-1H-indole-2-carboxylate. This compound acts as a key intermediate towards phosphoindole inhibitors, which are researched for their potential activity against HIV non-nucleoside reverse transcriptase. The precision of the halogen placement is crucial for the biological activity of the final drug molecule.
Additionally, this material is utilized in the synthesis of specific impurity standards related to tyrosine kinase inhibitors such as Gefitinib. Producing accurate impurity profiles is essential for regulatory filings and quality control in API manufacturing. Our product supports research teams aiming to develop next-generation oncology treatments and antiretroviral therapies. The high purity level ensures minimal side reactions during downstream synthesis steps, improving overall yield and efficiency.
Storage and Handling
To maintain the integrity of 4-Chloro-3-fluoroaniline, proper storage conditions are essential. The product should be kept in a tightly closed container to prevent exposure to moisture and air. Storage areas must be cool, dry, and well-ventilated, away from incompatible substances such as strong oxidizing agents. Standard personal protective equipment, including gloves and safety goggles, should be worn during handling to ensure operator safety. We package the material in 25kg drums suitable for secure global shipping. Our logistics team ensures timely delivery while adhering to all international chemical transportation regulations.
