Intermediates

4-Chloro-3-fluorobenzaldehyde

  • CAS No.5527-95-7
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 4-Chloro-3-fluorobenzaldehyde (CAS 5527-95-7) designed for advanced organic synthesis. Reliable supply with ≥99.0% purity for pharmaceutical and chemical manufacturing.

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Product Technical Details

Product Overview

4-Chloro-3-fluorobenzaldehyde is a highly specialized halogenated aromatic compound that serves as a critical building block in modern organic synthesis. As a key intermediate, this fluorinated benzaldehyde derivative is extensively utilized in the development of advanced pharmaceutical agents, agrochemical formulations, and functional materials. The unique substitution pattern featuring both chlorine and fluorine atoms on the benzene ring provides distinct reactivity profiles, enabling chemists to perform selective transformations that are essential for constructing complex molecular architectures. Our facility produces this compound under strict quality control standards to ensure consistency and reliability for large-scale industrial applications.

The presence of the aldehyde functional group combined with halogen substituents makes this molecule a versatile electrophile in various coupling reactions. It is particularly valued in medicinal chemistry where fluorine incorporation often enhances metabolic stability and bioavailability of the final active pharmaceutical ingredients. Manufacturers rely on high-purity grades to minimize side reactions during downstream synthesis steps, ensuring higher yields and reduced waste in production processes.

Technical Specifications

We adhere to rigorous analytical protocols to verify the identity and purity of every batch. The following table outlines the standard physical and chemical properties associated with this product. Custom specifications may be available upon request for specific research or production requirements.

ParameterValue
CAS Number5527-95-7
Molecular FormulaC7H4ClFO
Molecular Weight158.56 g/mol
AppearanceWhite Powder
Purity≥99.0%
Melting Point46-49°C
Boiling Point217.1°C
Density1.336 g/cm3

Industrial Applications

This chemical intermediate finds widespread utility across multiple sectors of the fine chemical industry. In pharmaceutical manufacturing, it acts as a precursor for synthesizing novel therapeutic compounds targeting various biological pathways. The fluorine atom introduces specific electronic effects that can modulate the potency and selectivity of drug candidates. Additionally, the chloro group offers a handle for further functionalization through cross-coupling methodologies such as Suzuki or Buchwald reactions.

Beyond healthcare, this compound is employed in the agrochemical sector for developing crop protection agents. Its stability and reactivity profile make it suitable for creating herbicides and pesticides that require precise molecular structures to achieve efficacy while maintaining environmental safety standards. Material science researchers also utilize this benzaldehyde derivative in the synthesis of polymers and liquid crystals where specific optical or electronic properties are desired.

Quality Assurance and Logistics

Our commitment to quality ensures that every drum meets the specified purity levels. We provide comprehensive documentation including Certificates of Analysis (COA) with each shipment. The product is packaged in 25 kg drums designed to protect the material from moisture and contamination during transit. For larger volume requirements, we offer flexible packaging solutions tailored to customer logistics needs.

Proper storage is essential to maintain product integrity. We recommend storing 4-Chloro-3-fluorobenzaldehyde in a cool, well-ventilated area away from direct sunlight and incompatible substances. Our global supply chain network enables timely delivery to laboratories and production facilities worldwide, supporting continuous manufacturing operations without interruption.