Intermediates

4-Chloro-3-fluorobenzoic acid

  • CAS No.403-17-8
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 4-Chloro-3-fluorobenzoic acid (CAS 403-17-8) designed for advanced organic synthesis. Reliable supply with ≥99.0% purity for pharmaceutical and agrochemical manufacturing.

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Product Technical Details

Product Overview

4-Chloro-3-fluorobenzoic acid is a highly valued halogenated aromatic compound serving as a critical building block in modern organic synthesis. Characterized by the presence of both chloro and fluoro substituents on the benzoic acid backbone, this molecule offers unique reactivity profiles that are essential for constructing complex pharmaceutical agents and agrochemical formulations. Our facility specializes in the production of this intermediate with strict adherence to international quality standards, ensuring consistency for downstream manufacturing processes.

The strategic positioning of the halogen atoms allows for versatile functionalization through nucleophilic aromatic substitution or cross-coupling reactions. This makes the compound an indispensable precursor for medicinal chemists aiming to develop novel therapeutic molecules with improved metabolic stability and bioavailability. We understand the rigorous demands of the fine chemical industry and provide material that meets exacting specifications for research and large-scale production.

Technical Specifications

ParameterValue
Chemical Name4-Chloro-3-fluorobenzoic acid
CAS Number403-17-8
Molecular FormulaC7H4ClFO2
Molecular Weight174.56 g/mol
Purity (HPLC)≥99.0%
AppearanceWhite powder
Melting Point190-192°C
Density1.477 g/cm³
Boiling Point287.4°C

Industrial Applications

This fluorinated benzoic acid derivative finds extensive utility across multiple high-tech sectors. In the pharmaceutical industry, it is frequently employed as a key intermediate in the synthesis of kinase inhibitors and anti-inflammatory drugs. The fluorine atom contributes to enhanced lipophilicity and membrane permeability, while the chloro group provides a handle for further chemical modification. Additionally, the compound is utilized in the agrochemical sector for the development of advanced herbicides and fungicides that require robust chemical stability in various environmental conditions.

  • Pharmaceutical intermediate for API synthesis
  • Building block for liquid crystal materials
  • Precursor for agrochemical active ingredients
  • Reagent for organic chemistry research
  • Component in polymer modification processes

Quality Assurance and Logistics

Quality control is paramount in our manufacturing process. Every batch of 4-Chloro-3-fluorobenzoic acid undergoes rigorous testing using high-performance liquid chromatography to verify purity levels. We provide a comprehensive Certificate of Analysis (COA) with every shipment, detailing all relevant physical and chemical properties. Our production facility maintains a cool and ventilated storage environment to preserve the integrity of the product during warehousing.

We offer flexible packaging options to suit diverse client needs, typically supplying in 25 kg drums but accommodating custom requirements upon request. Our logistics network ensures timely global delivery with proper hazardous material handling protocols. As a dedicated global manufacturer, we are committed to supporting your supply chain with stable inventory levels and competitive bulk pricing. Contact our technical sales team today to discuss your specific synthesis requirements and request a sample for evaluation.