(4-Chloro-3-fluorophenyl)acetonitrile

Product Overview

(4-Chloro-3-fluorophenyl)acetonitrile is a specialized fluorinated organic compound that serves as a vital building block in modern chemical synthesis. This substance is characterized by its unique substitution pattern, featuring both chloro and fluoro groups on the phenyl ring, which imparts distinct chemical reactivity and metabolic stability properties. As a key intermediate, it is extensively utilized in the development of complex pharmaceutical agents, agrochemical formulations, and advanced material science projects. Our facility ensures that every batch meets rigorous international standards for purity and consistency, supporting large-scale industrial production and research initiatives.

Physical And Chemical Properties

This compound presents as a colourless low melting solid under standard conditions, facilitating easy handling and integration into various reaction pathways. The molecular structure, defined by the formula C8H5ClFN, offers a molecular weight of approximately 169.583 g/mol. Key physical parameters include a density of 1.3±0.1 g/cm3 and a boiling point of 253.4±25.0 °C at 760 mmHg. The flash point is recorded at 107.1±23.2 °C, indicating standard safety protocols should be observed during storage and transport. With a vapour pressure of 0.0±0.5 mmHg at 25°C, the material exhibits low volatility, enhancing stability during prolonged storage periods. The index of refraction is measured at 1.528, confirming its optical purity and structural integrity.

Industrial Applications

The primary application of (4-Chloro-3-fluorophenyl)acetonitrile lies in its role as a versatile intermediate for organic synthesis. The presence of the nitrile group allows for further functionalization through hydrolysis, reduction, or Grignard reactions, making it indispensable for constructing complex molecular architectures. In the pharmaceutical sector, fluorinated intermediates are highly valued for their ability to improve the bioavailability and metabolic stability of drug candidates. This specific compound is often employed in the synthesis of kinase inhibitors, receptor modulators, and other therapeutic agents targeting chronic diseases. Additionally, it finds utility in agrochemical research, where fluorinated structures contribute to enhanced pesticidal activity and environmental persistence profiles. Our clients leverage this material for custom synthesis projects requiring high precision and reliability.

Quality Specifications

We maintain strict quality control measures to ensure product reliability. The assay purity is guaranteed to be ≥98.0%, minimizing impurities that could affect downstream reaction yields. Below is a summary of the key specification parameters:

Storage And Handling

To maintain optimal quality, this product should be stored in a cool, ventilated place away from direct sunlight and moisture. Containers must be kept tightly closed when not in use to prevent contamination. Standard industrial safety measures apply, including the use of appropriate personal protective equipment during handling. We offer flexible packaging options, including 25 kg drums, and can accommodate specific customer requirements for bulk shipments. Global logistics support ensures timely delivery with full documentation, including Certificate of Analysis (COA) and safety data sheets. Partner with us for a reliable supply chain of high-performance chemical intermediates.