Intermediates

4-Chloro-3-methylisoxazol-5-amine

  • CAS No.166964-09-6
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity pharmaceutical intermediate used in the synthesis of Sitaxentan sodium. Available in bulk quantities with strict quality control and global shipping options.

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Product Technical Details

Product Overview

4-Chloro-3-methylisoxazol-5-amine represents a critical heterocyclic building block within the pharmaceutical industry. This specialized organic compound is engineered for high-performance synthesis applications, particularly in the development of advanced therapeutic agents. Our manufacturing process ensures exceptional consistency, making it an ideal choice for research laboratories and large-scale production facilities requiring reliable raw materials.

The chemical structure features a substituted isoxazole ring, which provides unique reactivity profiles essential for complex multi-step synthesis routes. As a key precursor, it facilitates the construction of sophisticated molecular architectures required in modern medicinal chemistry. We prioritize purity and stability to support downstream processing efficiency.

Technical Specifications

Quality is paramount in pharmaceutical manufacturing. Our production facilities adhere to rigorous standards to guarantee that every batch meets or exceeds industry expectations. The following table outlines the critical physical and chemical parameters verified through advanced analytical methods.

Parameter Value
CAS Number 166964-09-6
Molecular Formula C4H5ClN2O
Molecular Weight 132.548
Appearance Off-white powder
Assay (HPLC) ≥99.0%
Loss on Drying ≤0.5%
Density 1.4±0.1 g/cm3
Boiling Point 245.1±35.0 °C at 760 mmHg
Flash Point 102.0±25.9 °C

Industrial Applications

This compound serves primarily as a vital intermediate in the synthesis of specific pharmaceutical agents, including endothelin receptor antagonists such as Sitaxentan sodium. Its high reactivity and stability make it suitable for various organic transformation processes. Chemists utilize this building block to introduce specific functional groups into larger molecular frameworks, enabling the creation of potent active pharmaceutical ingredients.

Beyond specific API synthesis, 4-Chloro-3-methylisoxazol-5-amine is valuable in agrochemical research and fine chemical production. The versatility of the isoxazole moiety allows for diverse derivatization, supporting innovation in multiple sectors. Our team provides technical documentation to assist process chemists in integrating this material into their existing workflows.

Quality Assurance and Safety

We implement a comprehensive quality management system to monitor every stage of production. Each batch undergoes strict testing using High-Performance Liquid Chromatography (HPLC) and other spectroscopic methods to confirm identity and purity. A Certificate of Analysis (COA) is provided with every shipment, ensuring full traceability and compliance with regulatory requirements.

Safety during handling is essential. While this material is intended for industrial and laboratory use, appropriate personal protective equipment should be worn. Storage conditions require a cool, ventilated environment to maintain stability over extended periods. Our packaging solutions are designed to prevent moisture ingress and contamination during transit.

Packaging and Logistics

Standard packaging consists of 25 kg drums, ensuring secure containment for bulk shipments. However, we understand that different projects have varying needs. Therefore, we offer custom packaging solutions tailored to specific customer requirements. Our logistics network supports global shipping, delivering materials promptly to destinations worldwide while maintaining chain of custody integrity.

For inquiries regarding bulk pricing, technical data sheets, or sample requests, our sales team is ready to assist. We are committed to fostering long-term partnerships through reliability, transparency, and superior product performance.