4-Chloro-3-(trifluoromethyl)phenyl Isocyanate
- CAS No.327-78-6
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 4-Chloro-3-(trifluoromethyl)phenyl Isocyanate (CAS 327-78-6) for pharmaceutical synthesis. Reliable supplier for Sorafenib intermediates with strict quality control.
Request Bulk PricingProduct Technical Details
Product Overview
4-Chloro-3-(trifluoromethyl)phenyl Isocyanate is a critical pharmaceutical intermediate widely utilized in the synthesis of advanced therapeutic compounds. As a key building block, this chemical plays an essential role in the manufacturing pipeline of kinase inhibitors, specifically serving as a precursor for Sorafenib Tosylate. Our facility ensures that every batch meets rigorous international standards, providing pharmaceutical manufacturers with a reliable source of high-quality raw materials for drug development.
This compound is characterized by its high reactivity and stability under controlled conditions, making it an ideal choice for complex organic synthesis routes. The presence of both chloro and trifluoromethyl groups enhances its electronic properties, facilitating efficient coupling reactions in the production of antiproliferative agents. We prioritize consistency and purity to support downstream processing and final API quality.
Key Specifications
Quality assurance is paramount in pharmaceutical manufacturing. Our production process involves multiple purification steps to ensure the removal of impurities and moisture. The following table outlines the standard specifications for our commercial grade material, which consistently exceeds industry benchmarks for purity and safety.
| Parameter | Specification |
|---|---|
| Appearance | White crystalline powder |
| Purity (HPLC) | ≥98.0% |
| Water Content | ≤0.5% |
| Impurity A | ≤0.15% |
| Impurity B | ≤1.0% |
| Total Impurities | ≤2.0% |
| Molecular Formula | C8H3ClF3NO |
| Molecular Weight | 221.56 g/mol |
Industrial Applications
The primary application of 4-Chloro-3-(trifluoromethyl)phenyl Isocyanate lies in the pharmaceutical sector, specifically within oncology research and development. It is extensively used to synthesize pyrimidinylaminobenzene derivatives, which exhibit significant antiproliferative activity against various melanoma cell lines. Furthermore, this intermediate is instrumental in the creation of alpha-thymidine analogues that function as potent antimalarial agents.
As a designated intermediate for Sorafenib, a multi-kinase inhibitor used in the treatment of renal cell carcinoma and hepatocellular carcinoma, the quality of this chemical directly impacts the efficacy and safety of the final drug product. Our manufacturing process is designed to minimize variability, ensuring that synthesis routes remain robust and scalable for large-scale API production.
Quality Assurance and Storage
We implement strict quality control measures throughout the production cycle. Each batch undergoes comprehensive testing using IR and HPLC methods to confirm identity and purity. A Certificate of Analysis (COA) is provided with every shipment to verify compliance with specified parameters. Proper storage is essential to maintain the integrity of the isocyanate group.
Products are packaged in 25kg cardboard drums or according to specific customer requirements. To prevent degradation, materials must be stored in a tightly closed container within a cool, dry, and well-ventilated area. It is crucial to keep the substance away from incompatible materials such as strong oxidizing agents, acids, and moisture. Adhering to these storage guidelines ensures optimal performance during subsequent chemical reactions.
