4-Chloro-6-ethyl-5-fluoropyrimidine
- CAS No.137234-74-3
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 4-Chloro-6-ethyl-5-fluoropyrimidine (CAS 137234-74-3) is a critical pharmaceutical intermediate used primarily in the synthesis of Voriconazole. Available in bulk quantities with strict quality control.
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Product Overview
4-Chloro-6-ethyl-5-fluoropyrimidine is a specialized heterocyclic building block designed for advanced pharmaceutical synthesis. As a fluorinated pyrimidine derivative, this compound plays a pivotal role in the construction of complex active pharmaceutical ingredients (APIs). Our manufacturing process ensures exceptional chemical stability and reactivity, making it an ideal choice for research and development teams focused on antifungal therapeutics and other medicinal chemistry applications.
We understand the critical nature of supply chain reliability in the pharmaceutical industry. Therefore, this intermediate is produced under stringent quality management systems to guarantee consistency across batches. Whether utilized for process development or large-scale production, our material meets the rigorous demands of modern drug synthesis.
Technical Specifications
The following table outlines the key physical and chemical properties verified through our internal quality control laboratories. Each batch is accompanied by a Certificate of Analysis (COA) to ensure transparency and compliance with specified standards.
| Parameter | Specification |
|---|---|
| CAS Number | 137234-74-3 |
| Molecular Formula | C6H6ClFN2 |
| Molecular Weight | 160.577 g/mol |
| Appearance | Light brown to colorless liquid |
| Assay (HPLC) | ≥98.0% |
| Moisture Content | ≤1.0% |
| Density | 1.3±0.1 g/cm3 |
| Boiling Point | 210.9±35.0 °C at 760 mmHg |
| Flash Point | 81.4±25.9 °C |
Industrial Applications
This fluorinated pyrimidine derivative serves as a key precursor in the synthesis of Voriconazole, a widely recognized antifungal agent. The presence of both chloro and fluoro substituents on the pyrimidine ring enables specific nucleophilic substitution reactions essential for building the final drug molecule. Beyond this primary application, the compound is valuable in various organic synthesis pathways where heterocyclic scaffolds are required.
- Pharmaceutical intermediate for antifungal agents
- Building block for medicinal chemistry R&D
- Reagent for heterocyclic compound synthesis
- Material for process optimization studies
Quality Assurance and Safety
Quality is the cornerstone of our manufacturing philosophy. Every production lot undergoes comprehensive testing using high-performance liquid chromatography (HPLC) and Karl Fischer titration to verify purity and moisture levels. We maintain detailed records for traceability and adhere to international safety standards for chemical handling.
For storage, the product should be kept in a cool, ventilated area away from direct sunlight and incompatible materials. We offer flexible packaging options, including 200 kg drums, to suit diverse logistical requirements. Our team is committed to providing global manufacturers with reliable access to high-quality chemical intermediates, supported by responsive technical service and documentation.
