4-Chloromethyl-5-methyl-1,3-dioxol-2-one
- CAS No.80841-78-7
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 4-Chloromethyl-5-methyl-1,3-dioxol-2-one (CAS 80841-78-7) designed for pharmaceutical synthesis. Reliable intermediate for Olmesartan production with ≥92% purity.
Request Bulk PricingProduct Technical Details
Product Overview
4-Chloromethyl-5-methyl-1,3-dioxol-2-one is a specialized organic compound widely recognized for its critical role in the synthesis of advanced pharmaceutical active ingredients. As a key structural building block, this chemical facilitates the construction of complex molecular architectures required in modern medicinal chemistry. Our manufacturing process ensures consistent quality, making it an ideal choice for research laboratories and large-scale production facilities focused on cardiovascular therapeutic agents.
This compound features a dioxolone ring structure substituted with chloromethyl and methyl groups, providing unique reactivity profiles essential for specific coupling reactions. The stability and purity of this intermediate directly influence the efficiency and yield of downstream API synthesis, particularly in the production of angiotensin II receptor blockers.
Technical Specifications
We adhere to strict quality control protocols to guarantee that every batch meets rigorous industry standards. The following table outlines the primary physical and chemical properties verified during our quality assurance process.
| Parameter | Specification |
|---|---|
| CAS Number | 80841-78-7 |
| Molecular Formula | C5H5ClO3 |
| Molecular Weight | 148.54 g/mol |
| Appearance | Yellow to yellow-brown liquid |
| Purity | ≥92.0% |
| Water Content | ≤0.5% |
| Density | 1.362 g/cm³ |
| Boiling Point | 163.2°C at 760 mmHg |
| Flash Point | 66.7°C |
| Refractive Index | 1.481 |
Industrial Applications
The primary application of 4-Chloromethyl-5-methyl-1,3-dioxol-2-one lies in the pharmaceutical sector, specifically serving as a vital intermediate in the synthesis of Olmesartan medoxomil. This antihypertensive agent requires precise chemical precursors to ensure efficacy and safety in the final medication. Beyond this specific use, the compound serves as a versatile reagent in organic synthesis, enabling chemists to introduce specific functional groups into larger molecular frameworks.
Our clients utilize this material for process development, scale-up studies, and commercial manufacturing. The high purity levels reduce the burden on downstream purification steps, thereby optimizing overall production costs and timelines. Whether used in pilot plants or full-scale manufacturing, this intermediate supports the reliable production of life-saving medications.
Quality Assurance and Storage
Maintaining the integrity of this chemical compound requires careful handling and storage procedures. We implement comprehensive quality assurance measures, including batch-specific testing and Certificate of Analysis (COA) provision for every shipment. Our facilities comply with international safety and environmental standards to ensure product stability from production to delivery.
- Store in a cool, dry, and well-ventilated area away from direct sunlight.
- Keep containers tightly closed to prevent moisture absorption and contamination.
- Avoid exposure to strong heat sources or incompatible materials.
- Use appropriate personal protective equipment during handling and transfer.
- Regularly inspect packaging for integrity during long-term storage.
Proper storage conditions are essential to maintain the specified purity and physical properties over time. Deviations from recommended storage protocols may lead to degradation or changes in physical appearance, potentially affecting downstream reaction efficiency.
Packaging and Logistics
We offer flexible packaging solutions to meet diverse customer requirements. Standard packaging includes 25kg cardboard drums, which are designed to protect the contents during transit while ensuring ease of handling in industrial settings. Custom packaging configurations are available upon request to accommodate specific logistical needs or bulk orders.
Our global supply chain network ensures timely delivery to manufacturers worldwide. We prioritize secure shipping methods that comply with hazardous material regulations where applicable. For detailed information regarding shipping lead times, bulk pricing structures, or custom synthesis capabilities, please contact our technical sales team for a comprehensive consultation.
