4-Chloropyrrolo[2,3-d]pyrimidine

Product Overview

4-Chloropyrrolo[2,3-d]pyrimidine (CAS 3680-69-1) is a high-value heterocyclic building block widely employed in the synthesis of advanced pharmaceutical actives. This compound serves as a critical intermediate in the production of Janus kinase (JAK) inhibitors, most notably Tofacitinib (CAS 477600-75-2), a clinically approved therapeutic for autoimmune disorders. Our product is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and compliance with international regulatory standards.

Specifications

Industrial Applications

As a versatile pyrrolopyrimidine scaffold, this intermediate enables efficient construction of complex purine analogs. Its primary application lies in the multi-step synthesis of Tofacitinib, where it functions as a core structural precursor. Beyond this, it is also utilized in medicinal chemistry research for developing novel kinase inhibitors targeting inflammatory and oncological pathways.

• Serves as a foundational building block in JAK inhibitor synthesis
• Compatible with standard cross-coupling and nucleophilic substitution reactions
• Supplied in pharma-grade purity suitable for regulated API manufacturing
• Stable under recommended storage conditions for extended shelf life

Packaged in 25 kg fiber drums or customized containers upon request, 4-Chloropyrrolo[2,3-d]pyrimidine should be stored in a cool, dry, and well-ventilated area away from incompatible materials. Full documentation including Certificate of Analysis (COA) and safety data is available to support regulatory submissions and process validation.