Intermediates

4-Cyanopyridine

  • CAS No.100-48-1
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 4-Cyanopyridine (CAS 100-48-1) designed for pharmaceutical synthesis. Reliable supply for Topiroxostat intermediates with strict quality control.

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Product Technical Details

Product Overview

4-Cyanopyridine, also known as Isonicotinonitrile, is a critical heterocyclic organic compound widely utilized in the pharmaceutical and agrochemical industries. As a key building block, it serves as an essential intermediate in the synthesis of various active pharmaceutical ingredients (APIs). Our facility specializes in the production of this high-value chemical, ensuring consistent quality and supply chain stability for global partners.

We understand the rigorous demands of modern medicinal chemistry. Therefore, our 4-Cyanopyridine is manufactured under strict quality management systems to meet international standards. Whether used in the development of novel therapeutics or large-scale commercial production, our product provides the reliability required for complex synthetic routes.

Key Specifications

ParameterSpecification
CAS Number100-48-1
Molecular FormulaC6H4N2
Molecular Weight104.11 g/mol
Purity≥99.0%
AppearanceWhite Crystalline Powder
Water Content≤0.5%
Sulfated Ash≤0.1%
Heavy Metals≤10 ppm
Total Impurity≤0.2%

Physical and Chemical Properties

This compound exhibits distinct physical properties that facilitate its handling and integration into various synthesis processes. It presents as a white crystalline powder with a melting point ranging between 76 to 79 degrees Celsius. The boiling point is approximately 196 degrees Celsius, and it possesses a density of 1.12 grams per cubic centimeter. With a flash point of 88 degrees Celsius, appropriate safety measures should be maintained during storage and transportation. The refractive index is recorded at 1.539, confirming its structural integrity and purity levels.

Industrial Applications

4-Cyanopyridine is predominantly employed as a versatile intermediate in organic synthesis. Its primary application lies in the pharmaceutical sector, where it acts as a precursor for the synthesis of Topiroxostat, a notable xanthine oxidase inhibitor used in the management of hyperuricemia and gout. Beyond this specific application, the nitrile group on the pyridine ring allows for diverse chemical transformations, including hydrolysis to acids or reduction to amines, making it invaluable for medicinal chemists designing new molecular entities.

Quality Assurance and Packaging

Quality is the cornerstone of our manufacturing process. Every batch of 4-Cyanopyridine undergoes comprehensive testing using advanced analytical techniques such as HPLC and GC-MS to verify purity and identity. We provide a Certificate of Analysis (COA) with every shipment to ensure transparency and compliance. The product is packaged in 25kg cardboard drums, though custom packaging solutions are available upon request to suit specific logistical needs.

For storage, we recommend keeping the container tightly closed in a cool, dry, and well-ventilated area. It should be stored away from incompatible substances to maintain stability. Our team offers dedicated technical support to assist with integration into your production lines, ensuring a seamless experience from order to delivery.