4-Difluoromethoxy-3-Hydroxybenzaldehyde
- CAS No.151103-08-1
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 4-Difluoromethoxy-3-Hydroxybenzaldehyde serves as a critical intermediate for Roflumilast synthesis. Reliable supply for pharmaceutical manufacturing with full documentation.
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Product Overview
4-Difluoromethoxy-3-Hydroxybenzaldehyde is a specialized organic compound widely recognized for its pivotal role in the pharmaceutical industry. As a key building block, this substance is primarily utilized in the synthesis of advanced therapeutic agents, specifically within the class of phosphodiesterase-4 (PDE4) inhibitors. Our manufacturing process ensures that every batch meets stringent quality standards, providing consistency and reliability for downstream chemical synthesis operations.
This compound features a unique difluoromethoxy group attached to a hydroxybenzaldehyde core, offering specific reactivity profiles essential for complex molecular construction. The precise arrangement of functional groups allows chemists to execute selective transformations required for producing high-value active pharmaceutical ingredients (APIs). We maintain rigorous control over production parameters to guarantee optimal purity and performance.
Technical Specifications
| Parameter | Value |
|---|---|
| CAS Number | 151103-08-1 |
| Molecular Formula | C8H6F2O3 |
| Molecular Weight | 188.128 |
| Appearance | Off-white powder |
| Assay | ≥99.0% |
| Water Content | ≤0.50% |
| Density | 1.4±0.1 g/cm3 |
| Boiling Point | 280.6±35.0 °C at 760 mmHg |
| Flash Point | 123.5±25.9 °C |
Industrial Applications
The primary application of 4-Difluoromethoxy-3-Hydroxybenzaldehyde lies in the preparation of Roflumilast intermediates. Roflumilast is a well-known medication used in the management of chronic obstructive pulmonary disease (COPD), making this intermediate a vital component in the global supply chain for respiratory therapeutics. The high purity levels we provide are crucial for ensuring the safety and efficacy of the final drug product.
Beyond its specific use in PDE4 inhibitor synthesis, this chemical serves as a versatile precursor in organic chemistry laboratories. Researchers utilize it for developing new synthetic routes and optimizing reaction conditions. Its stability and reactivity make it suitable for various scaling processes, from pilot plant studies to full-scale commercial manufacturing.
Quality Assurance and Storage
We understand that consistency is paramount in pharmaceutical synthesis. Therefore, each production lot undergoes comprehensive analytical testing. Certificates of Analysis (COA) are provided with every shipment, detailing critical parameters such as assay purity, moisture content, and physical characteristics. Our quality management system adheres to international standards to support our clients' regulatory compliance needs.
Proper storage is essential to maintain the integrity of this chemical. It should be kept in a cool, dry, and well-ventilated area. Containers must remain tightly closed to prevent exposure to moisture and air, which could affect stability. We offer flexible packaging options, including 25kg drums, and can customize solutions based on specific logistical requirements. Our global distribution network ensures timely delivery to support uninterrupted production schedules.
