4-(Difluoromethoxy)nitrobenzene
- CAS No.1544-86-1
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 4-(Difluoromethoxy)nitrobenzene (CAS 1544-86-1) designed for advanced organic synthesis. Reliable supply with ≥98.0% assay for industrial applications.
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Product Overview
4-(Difluoromethoxy)nitrobenzene is a specialized fluorinated aromatic intermediate designed for complex organic synthesis applications. As a key building block in the pharmaceutical and agrochemical industries, this compound offers exceptional stability and reactivity profiles required for advanced molecular construction. Our manufacturing process ensures high purity levels, making it an ideal choice for researchers and industrial chemists seeking reliable raw materials for multi-step synthesis routes. The strategic placement of the nitro group para to the difluoromethoxy substituent allows for versatile chemical transformations, enabling chemists to access a wide range of downstream derivatives efficiently.
The incorporation of the difluoromethoxy group enhances the metabolic stability and lipophilicity of downstream molecules, which is crucial in modern medicinal chemistry. We supply this chemical under strict quality control standards, guaranteeing consistency across batches for large-scale production needs. Our facility adheres to international safety and environmental regulations, ensuring that every kilogram produced meets the highest industry benchmarks for purity and performance.
Technical Specifications
| Parameter | Value |
|---|---|
| CAS Number | 1544-86-1 |
| Molecular Formula | C7H5F2NO3 |
| Molecular Weight | 189.116 g/mol |
| Appearance | Light yellow liquid or crystalline powder |
| Assay | ≥98.0% |
| Melting Point | 37-40 °C |
| Boiling Point | 259.6±30.0 °C |
| Density | 1.4±0.1 g/cm3 |
| Flash Point | 110.8±24.6 °C |
Industrial Applications
This fluorinated intermediate serves as a versatile precursor in the synthesis of various bioactive compounds. It is frequently utilized in nucleophilic aromatic substitution reactions where the nitro group acts as a leaving group activator. The difluoromethoxy moiety is particularly valued for its ability to modulate the electronic properties of aromatic rings, facilitating specific coupling reactions. In the context of drug discovery, this scaffold is often employed to optimize the pharmacokinetic properties of lead compounds without compromising biological activity.
- Ideal for pharmaceutical process development and scale-up.
- Used in the preparation of agrochemical active ingredients.
- Suitable for materials science research involving fluorinated polymers.
- Effective reagent for introducing difluoromethoxy groups into complex architectures.
Quality Assurance and Storage
Every batch of 4-(Difluoromethoxy)nitrobenzene undergoes rigorous analytical testing, including HPLC and NMR spectroscopy, to verify identity and purity. We provide a comprehensive Certificate of Analysis (COA) with each shipment. To maintain product integrity, store the material in a cool, ventilated area away from direct sunlight and incompatible substances. Packaging is available in 25 kg drums or customized according to specific client requirements to ensure safe transport and handling. Our logistics team ensures timely delivery while maintaining compliance with hazardous material transportation regulations.
For technical inquiries or custom synthesis requests, our expert support team is available to assist with formulation guidance and safety data sheets. We are committed to supporting our partners with consistent supply chains and transparent communication throughout the procurement process.
