Intermediates

4-Ethyl-5-Fluoro-6-Hydroxypyrimidine

  • CAS No.137234-87-8
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 4-Ethyl-5-Fluoro-6-Hydroxypyrimidine (CAS 137234-87-8) designed for pharmaceutical synthesis. Reliable supply for Voriconazole production with strict quality control.

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Product Technical Details

Product Overview

4-Ethyl-5-Fluoro-6-Hydroxypyrimidine is a specialized heterocyclic compound serving as a critical building block in modern medicinal chemistry. Identified by CAS number 137234-87-8, this fluorinated pyrimidine derivative is engineered to meet the rigorous demands of pharmaceutical manufacturing. Our facility produces this intermediate using advanced organic synthesis techniques, ensuring consistent molecular integrity and high chemical purity. The presence of the fluoro substituent enhances the metabolic stability and bioavailability of downstream active pharmaceutical ingredients, making it a valuable component in the development of antifungal therapies.

We understand that precision is paramount in API synthesis. Therefore, our production process focuses on minimizing impurities and maximizing yield. This compound is particularly recognized for its role in the synthesis of Voriconazole, a broad-spectrum antifungal agent. By supplying this key intermediate, we support global pharmaceutical partners in maintaining efficient production schedules and complying with international regulatory standards.

Technical Specifications

Quality control is integral to our manufacturing workflow. Each batch undergoes comprehensive analytical testing to verify compliance with specified parameters. The following table outlines the standard physical and chemical properties associated with this product:

ParameterSpecification
CAS Number137234-87-8
Molecular FormulaC6H7FN2O
Molecular Weight142.131 g/mol
AppearanceWhite to light yellow powder
Assay (HPLC)≥98.0%
Loss on Drying≤0.1%
Density1.3±0.1 g/cm3
Boiling Point180.724ºC at 760 mmHg
Flash Point63.1ºC

Industrial Applications

The primary application of 4-Ethyl-5-Fluoro-6-Hydroxypyrimidine lies within the pharmaceutical sector, specifically as a precursor for antifungal medications. Its chemical structure allows for versatile functionalization, enabling chemists to construct complex molecular architectures required for potent therapeutic agents. Beyond Voriconazole synthesis, this intermediate may be utilized in research and development settings for exploring new pyrimidine-based compounds with potential biological activity.

Our clients value this product for its reliability in multi-step synthesis routes. The high purity level reduces the need for extensive purification downstream, thereby optimizing overall production costs and time. Whether used in large-scale commercial manufacturing or pilot-scale experimental processes, this chemical delivers consistent performance.

Quality Assurance and Storage

We adhere to strict quality management systems to ensure product safety and efficacy. Every shipment is accompanied by a Certificate of Analysis (COA) detailing batch-specific test results. Our packaging solutions are designed to protect the material from moisture and light degradation during transit. Standard packaging includes 25 kg drums, though we offer flexible customization to meet specific logistical requirements.

For optimal stability, store this compound in a cool, ventilated area away from direct sunlight and incompatible substances. Proper handling procedures should be followed to maintain safety standards in the laboratory or production facility. Our team is available to provide technical support regarding storage conditions, safety data sheets, and regulatory documentation to facilitate smooth import and export processes.