Intermediates

4-Fluoro-2-nitrobenzoic acid

  • CAS No.394-01-4
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 4-Fluoro-2-nitrobenzoic acid (CAS 394-01-4) designed for advanced organic synthesis and pharmaceutical intermediate applications.

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Product Technical Details

Product Overview

4-Fluoro-2-nitrobenzoic acid is a highly specialized fluorinated aromatic compound that serves as a vital building block in the pharmaceutical and agrochemical industries. As a key intermediate, this compound facilitates the synthesis of complex molecular structures required for advanced therapeutic developments. Our manufacturing facility ensures consistent quality and high purity levels, making it an ideal choice for research laboratories and large-scale production environments alike.

The presence of both fluoro and nitro functional groups on the benzoic acid backbone provides unique reactivity profiles, enabling diverse chemical transformations. This versatility makes it a preferred starting material for nucleophilic aromatic substitution reactions and other critical synthetic pathways. We prioritize rigorous quality control measures to guarantee that every batch meets international standards for chemical intermediates.

Technical Specifications

ParameterSpecification
Chemical Name4-Fluoro-2-nitrobenzoic acid
CAS Number394-01-4
Molecular FormulaC7H4FNO4
Molecular Weight185.109 g/mol
AppearanceWhite to light yellow crystalline powder
Assay (Purity)≥98.0%
Melting Point147-148°C
Boiling Point343.8±27.0 °C at 760 mmHg
Density1.6±0.1 g/cm3

Industrial Applications

This chemical intermediate is extensively utilized in the preparation of various pharmaceutical agents and fine chemicals. Its structural properties allow for efficient incorporation into larger molecular frameworks, particularly in the development of kinase inhibitors and other targeted therapies. Additionally, it finds application in the synthesis of agrochemicals where fluorinated compounds are valued for their metabolic stability and bioavailability.

Researchers and process chemists rely on this material for its predictable reactivity and high consistency across batches. Whether used in medicinal chemistry campaigns or scale-up processes, 4-Fluoro-2-nitrobenzoic acid provides a reliable foundation for constructing complex organic molecules. Our team supports clients with technical data to optimize synthesis routes and improve overall yield efficiency.

Quality Assurance and Packaging

We maintain a robust quality management system to ensure product integrity from synthesis to delivery. Each production lot undergoes comprehensive analysis, including HPLC, NMR, and melting point determination, to verify compliance with specified standards. A Certificate of Analysis (COA) is provided with every shipment, detailing test results and confirming conformity to factory standards.

Standard packaging consists of 25 kg drums, designed to protect the material from moisture and contamination during transit. However, we offer flexible packaging solutions tailored to specific customer requirements, ensuring safe handling and storage regardless of order volume. Our logistics network supports global shipping, delivering materials promptly to facilities worldwide.

Storage and Handling

To maintain stability and safety, 4-Fluoro-2-nitrobenzoic acid should be stored in a cool, ventilated area away from direct sunlight and heat sources. Containers must remain tightly sealed when not in use to prevent exposure to humidity. Personnel handling this chemical should adhere to standard laboratory safety protocols, including the use of appropriate personal protective equipment such as gloves and safety goggles.

Proper storage conditions ensure the longevity of the product and prevent degradation over time. By following these guidelines, customers can maintain the high quality of the material throughout its shelf life. Our technical support team is available to provide additional safety data sheets and handling recommendations upon request.