Intermediates

4-Fluoro-3-(trifluoromethyl)phenol

  • CAS No.61721-07-1
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 4-Fluoro-3-(trifluoromethyl)phenol (CAS 61721-07-1) designed for advanced organic synthesis and pharmaceutical intermediate applications.

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Product Technical Details

Product Overview

4-Fluoro-3-(trifluoromethyl)phenol is a highly specialized fluorinated aromatic compound that serves as a critical building block in modern organic chemistry. Characterized by the presence of both fluorine and trifluoromethyl substituents on the phenolic ring, this molecule exhibits unique electronic properties that enhance its reactivity in nucleophilic substitution and coupling reactions. Our manufacturing process ensures consistent quality, making it an ideal candidate for complex synthetic pathways in the pharmaceutical and agrochemical sectors.

As a key intermediate, this compound provides excellent stability under various reaction conditions while maintaining high reactivity where required. The introduction of fluorine atoms often improves the metabolic stability and bioavailability of downstream products, which is why this chemical is frequently sought after for the development of advanced therapeutic agents and crop protection solutions.

Technical Specifications

ParameterValue
CAS Number61721-07-1
Molecular FormulaC7H4F4O
Molecular Weight180.100 g/mol
AppearanceLight yellow to yellow transparent liquid
Assay (Purity)≥98.0%
Density1.4±0.1 g/cm3
Boiling Point206.6±35.0 °C at 760 mmHg
Flash Point78.7±25.9 °C
Refractive Index1.440

Industrial Applications

This fluorinated phenol derivative is primarily utilized as a versatile intermediate in the synthesis of complex organic molecules. Its specific substitution pattern allows chemists to introduce fluorinated motifs into larger structures efficiently. Common applications include the preparation of pharmaceutical active pharmaceutical ingredients (APIs), where fluorine substitution is known to enhance drug efficacy and pharmacokinetic profiles.

Additionally, it serves as a valuable precursor in the agrochemical industry for producing herbicides and pesticides with improved environmental stability. The compound is also suitable for use in materials science, particularly in the development of polymers and liquid crystals where specific electronic characteristics are required. Researchers value this material for its reliability in cross-coupling reactions such as Suzuki or Buchwald-Hartwig aminations.

Quality Assurance and Handling

We adhere to strict quality control protocols to ensure every batch meets the specified purity levels of ≥98.0%. Each shipment is accompanied by a comprehensive Certificate of Analysis (COA) detailing physical and chemical properties. Our facility employs advanced analytical techniques, including HPLC and GC-MS, to verify composition and identify any potential impurities.

  • Packaged in 200 kg drums or according to specific customer requirements.
  • Stored in a cool, ventilated area away from direct sunlight and moisture.
  • Compatible with standard chemical handling procedures for fluorinated organics.
  • Global shipping capabilities with secure logistics partners.

For laboratories and industrial plants requiring consistent supply chains, we offer bulk pricing options and custom synthesis services. Our technical team is available to provide formulation guidance and safety data sheets to ensure safe integration into your production processes. Contact us today to discuss your specific requirements for 4-Fluoro-3-(trifluoromethyl)phenol.