Intermediates

4-Fluoroanisole

  • CAS No.459-60-9
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High purity 4-Fluoroanisole (CAS 459-60-9) designed for advanced organic synthesis. Reliable supply with strict quality control for pharmaceutical and agrochemical applications.

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Product Technical Details

Product Overview

4-Fluoroanisole, identified by CAS number 459-60-9, stands as a critical fluorinated aromatic ether utilized extensively within the fine chemical and pharmaceutical sectors. As a specialized building block, this compound offers unique reactivity profiles due to the presence of the fluorine atom at the para position relative to the methoxy group. Our manufacturing process ensures high chemical stability and consistency, making it an ideal candidate for complex multi-step synthesis pathways. The introduction of fluorine into organic molecules often enhances metabolic stability and bioavailability, which is why this intermediate is highly valued in modern medicinal chemistry research and development.

We are committed to supplying premium-grade materials that meet rigorous international standards. Each batch undergoes strict quality control protocols to verify identity and purity, ensuring that downstream reactions proceed with optimal efficiency. Whether used in the development of new active pharmaceutical ingredients or advanced agrochemical formulations, our 4-Fluoroanisole provides a reliable foundation for innovation. Our facility adheres to good manufacturing practices to guarantee product safety and traceability from raw material sourcing to final packaging.

Technical Specifications

The following table outlines the key physical and chemical properties associated with our standard production grade. These parameters are verified through advanced analytical techniques including gas chromatography and nuclear magnetic resonance spectroscopy to ensure compliance with stated specifications.

ParameterSpecification
CAS Number459-60-9
Molecular FormulaC7H7FO
Molecular Weight126.13 g/mol
AppearanceColorless transparent liquid
Assay (Purity)≥99.0%
Moisture Content≤0.2%
Boiling Point157°C
Density1.114 g/cm³
Refractive Index1.488

Industrial Applications

This fluorinated intermediate serves as a versatile precursor in various chemical transformations. Its primary utility lies in nucleophilic aromatic substitution reactions where the fluorine atom can be displaced by various nucleophiles. Additionally, the methoxy group can be demethylated to yield phenolic derivatives, offering further synthetic flexibility for chemists designing complex molecular architectures.

  • Pharmaceutical Synthesis: Used in the construction of kinase inhibitors and other therapeutic agents requiring fluorinated aromatic cores to improve drug likeness.
  • Agrochemical Development: Acts as a key starting material for herbicides and fungicides designed for enhanced environmental stability and efficacy.
  • Material Science: Employed in the production of specialized polymers and liquid crystal materials where specific electronic properties are required for performance.

Our team supports clients with comprehensive technical documentation including Certificates of Analysis (COA) and Material Safety Data Sheets (MSDS) to facilitate regulatory compliance and safe handling procedures across global borders.

Storage and Handling

To maintain product integrity, 4-Fluoroanisole should be stored in a cool, well-ventilated area away from direct sunlight and sources of ignition. Containers must be kept tightly sealed when not in use to prevent moisture absorption and oxidation which could degrade quality over time. We recommend using appropriate personal protective equipment during handling, including chemical-resistant gloves and safety goggles. For bulk orders, we offer flexible packaging solutions including 200 kg drums or customized containers based on specific logistical requirements. Our global supply chain ensures timely delivery while maintaining the highest safety standards throughout transportation and warehousing.