4-Fluorobenzaldehyde
- CAS No.459-57-4
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 4-Fluorobenzaldehyde (CAS 459-57-4) is a key fluorinated aromatic intermediate for pharmaceutical and agrochemical synthesis.
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Product Overview
4-Fluorobenzaldehyde is a high-value fluorinated aromatic aldehyde widely employed as a critical building block in the synthesis of active pharmaceutical ingredients (APIs), agrochemicals, and specialty fine chemicals. Its electron-withdrawing fluorine substituent enhances reactivity and metabolic stability in downstream molecular architectures, making it indispensable in modern medicinal chemistry workflows.
Specifications
| Molecular Formula | C₇H₅FO |
|---|---|
| Molecular Weight | 124.11 g/mol |
| Density | 1.157 g/cm³ |
| Melting Point | -10 °C |
| Boiling Point | 181 °C |
| Flash Point | 134 °F (56.7 °C) |
| Refractive Index | ~1.500 |
| Appearance | Colorless or light yellow transparent liquid |
| Purity (GC) | ≥99.5% |
Industrial Applications
As a versatile synthetic intermediate, 4-Fluorobenzaldehyde serves as a foundational scaffold in the production of numerous therapeutic agents, including:
- Antihypertensive medications targeting cardiovascular regulation
- Non-steroidal anti-inflammatory drugs (NSAIDs) with enhanced pharmacokinetic profiles
- Oncology therapeutics leveraging fluorine-modulated bioavailability
- Muscle relaxants and central nervous system modulators
Its utility extends to crop protection chemistry, where fluorinated motifs improve pesticide efficacy and environmental persistence under controlled regulatory frameworks.
Quality Assurance & Handling
Manufactured under stringent quality control protocols, our 4-Fluorobenzaldehyde meets or exceeds industry standards for impurity profiles, with individual byproducts such as ortho/meta isomers, benzaldehyde derivatives, and moisture consistently maintained below 0.1%. Supplied in 200 kg drums with custom packaging available, it should be stored in a cool, well-ventilated area away from oxidizing agents and ignition sources.
