Intermediates

4-Fluorophenol

  • CAS No.371-41-5
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity 4-Fluorophenol (CAS 371-41-5) is a key aromatic intermediate widely used in pharmaceutical and agrochemical synthesis.

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Product Technical Details

Product Overview

4-Fluorophenol is a high-value fluorinated aromatic compound extensively employed as a building block in the synthesis of active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials. With its electron-withdrawing fluorine substituent in the para position relative to the hydroxyl group, it offers unique reactivity and stability profiles that are critical in modern organic synthesis pathways.

Specifications

Molecular FormulaC6H5FO
Molecular Weight112.10 g/mol
CAS Number371-41-5
AppearanceLight yellow crystal
Assay≥99.5%
2-Fluorophenol≤0.2%
Phenol≤0.1%
Water Content≤0.5%
Melting Point43–46°C
Boiling Point185°C
Density1.22 g/cm³
Refractive Index1.523

Industrial Applications

As a versatile synthetic intermediate, 4-Fluorophenol serves as a foundational scaffold in the development of complex molecules. Its primary applications include:

  • Pharmaceutical R&D: Precursor for fluorinated drug candidates targeting central nervous system disorders, anti-infectives, and metabolic diseases.
  • Agrochemical Manufacturing: Intermediate in the production of herbicides, fungicides, and plant growth regulators requiring enhanced bioavailability and environmental persistence.
  • Material Science: Building block for liquid crystals, polymers, and photoresists used in advanced electronics and coatings.

Our 4-Fluorophenol is manufactured under stringent quality control protocols compliant with international standards, ensuring batch-to-batch consistency and traceability. Each shipment includes a comprehensive Certificate of Analysis (COA) and is packaged in 25 kg drums or customized containers upon request.

Storage & Handling

Store in a cool, dry, and well-ventilated area away from heat sources and incompatible materials. Keep container tightly closed to prevent moisture absorption and degradation. Use appropriate personal protective equipment during handling.