4-(Hexafluoro-2-hydroxyisopropyl)aniline
- CAS No.722-92-9
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity fluorinated aromatic intermediate used in pharmaceutical R&D and advanced material synthesis.
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Product Overview
4-(Hexafluoro-2-hydroxyisopropyl)aniline (CAS 722-92-9) is a highly specialized fluorinated aromatic amine featuring a geminal hexafluoroisopropyl alcohol moiety. This compound serves as a critical building block in the synthesis of complex organic molecules, particularly in medicinal chemistry and agrochemical innovation. Its unique electron-withdrawing trifluoromethyl groups impart enhanced metabolic stability, lipophilicity, and conformational rigidity—properties highly sought after in modern drug design.
Specifications
| Molecular Formula | C9H7F6NO |
|---|---|
| Molecular Weight | 259.15 g/mol |
| Appearance | Light brown crystalline powder |
| Melting Point | 155–157°C |
| Boiling Point | 292.9°C at 760 mmHg |
| Density | 1.505 g/cm³ |
| Refractive Index | 1.454 |
| Flash Point | 130.9°C |
| Storage Conditions | Keep cold under argon |
Industrial Applications
This fluorinated intermediate is primarily employed in research and development settings for the construction of novel bioactive compounds. Key application areas include:
- Pharmaceutical R&D: As a precursor for fluorine-containing active pharmaceutical ingredients (APIs) targeting CNS disorders, oncology, and anti-infective therapies.
- Agrochemical Innovation: In the design of next-generation pesticides and herbicides with improved environmental persistence profiles.
- Advanced Materials: For synthesizing fluorinated monomers used in high-performance polymers and electronic materials.
Due to its sensitivity to moisture and oxidation, strict handling protocols under inert atmosphere are recommended to maintain integrity and reactivity during synthetic transformations.
