Intermediates

4-Hydrazinobenzene-1-sulfonamide hydrochloride

  • CAS No.17852-52-7
  • GradeIndustrial / Pharmaceutical
  • Availability● In Stock

High-purity pharmaceutical intermediate for Celecoxib synthesis. Available in bulk quantities with strict quality control and COA.

Request Bulk Pricing

Product Technical Details

Product Overview

4-Hydrazinobenzene-1-sulfonamide hydrochloride is a specialized organic compound widely recognized in the pharmaceutical industry as a critical building block. This sulfonamide derivative serves as an essential precursor in the manufacturing of non-steroidal anti-inflammatory drugs (NSAIDs), specifically playing a pivotal role in the synthesis pathway of Celecoxib. Our facility produces this chemical under stringent quality management systems to ensure consistency and reliability for downstream pharmaceutical manufacturers.

As a key intermediate, this compound exhibits stable chemical properties suitable for large-scale industrial reactions. The hydrochloride salt form enhances stability and handling safety during storage and transport. We prioritize high purity levels to minimize impurities that could affect the efficacy and safety profile of the final active pharmaceutical ingredient (API).

Technical Specifications

Our production process adheres to rigorous analytical standards. Each batch undergoes comprehensive testing using high-performance liquid chromatography (HPLC) and other advanced spectroscopic methods to verify identity and purity. The physical characteristics are tightly controlled to meet global pharmacopoeia requirements.

ParameterSpecification
CAS Number17852-52-7
Molecular FormulaC6H10ClN3O2S
Molecular Weight223.68 g/mol
AppearanceLight yellow powder
Assay (Purity)≥98.0%
Melting Point217-219 ºC
Boiling Point434.7 ºC at 760 mmHg
Flash Point216.7 ºC

Industrial Applications

The primary application of 4-Hydrazinobenzene-1-sulfonamide hydrochloride is in the pharmaceutical sector. It acts as a nucleophilic reagent in the condensation reactions required to construct the pyrazole ring found in Celecoxib. The quality of this intermediate directly influences the reaction yield and the purification efficiency of the final drug substance.

  • Essential precursor for Celecoxib (CAS 169590-42-5) synthesis.
  • Used in the development of selective COX-2 inhibitors.
  • Applicable in research and development for new anti-inflammatory therapies.
  • Supports generic drug manufacturing processes requiring high consistency.

Quality Assurance And Logistics

We understand that supply chain reliability is crucial for pharmaceutical production. Our manufacturing plant is equipped to handle bulk orders with flexible packaging options to suit various logistical requirements. Every shipment is accompanied by a Certificate of Analysis (COA) detailing batch-specific test results.

Products are packaged in 25 kg drums or according to specific customer requirements. Storage recommendations include keeping the material in a cool, ventilated area away from direct sunlight and moisture to maintain stability. We offer global shipping services with comprehensive documentation to ensure smooth customs clearance and timely delivery to your facility.