4-Hydrazinobenzenesulfonamide
- CAS No.4392-54-5
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 4-Hydrazinobenzenesulfonamide (CAS 4392-54-5), a key pharmaceutical intermediate for Celecoxib synthesis. Ideal for GMP-compliant API manufacturing.
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Product Overview
4-Hydrazinobenzenesulfonamide is a high-value aromatic hydrazine derivative widely employed as a critical building block in the synthesis of selective cyclooxygenase-2 (COX-2) inhibitors. With a CAS number of 4392-54-5 and a molecular formula of C6H9N3O2S, this compound serves as an essential intermediate in the production of Celecoxib, a globally recognized nonsteroidal anti-inflammatory drug (NSAID). Our product is manufactured under stringent quality control protocols to ensure consistent purity and performance in advanced pharmaceutical applications.
Specifications
| Molecular Formula | C6H9N3O2S |
|---|---|
| Molecular Weight | 187.22 g/mol |
| Melting Point | 158–159 °C (lit.) |
| Boiling Point | 434.7 ± 47.0 °C at 760 mmHg |
| Density | 1.5 ± 0.1 g/cm³ |
| Flash Point | 216.7 ± 29.3 °C |
| Assay | ≥98.0% |
| Appearance | Off-white to light beige powder |
Industrial Applications
This compound is primarily utilized as a specialized intermediate in the multi-step synthesis of Celecoxib (CAS 169590-42-5). Its well-defined reactivity profile enables efficient construction of the pyrazole core structure characteristic of COX-2 selective inhibitors. As a result, it plays a pivotal role in the development of anti-inflammatory therapeutics within regulated pharmaceutical manufacturing environments.
- Enables robust and scalable synthetic routes for Celecoxib production
- Compatible with standard organic transformation protocols under GMP conditions
- Supplied with comprehensive analytical documentation including Certificate of Analysis (COA)
For optimal stability, store in a cool, dry, and well-ventilated area away from incompatible materials. Standard packaging is 25 kg per drum, with custom packaging options available upon request to meet specific logistical or regulatory requirements.
