4-Iodobenzotrifluoride
- CAS No.455-13-0
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High purity 4-Iodobenzotrifluoride is a premier aromatic intermediate designed for complex organic synthesis and cross-coupling reactions in pharmaceutical manufacturing.
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Product Overview
4-Iodobenzotrifluoride represents a critical class of fluorinated aromatic intermediates utilized extensively in modern organic synthesis. As a halogenated building block, this compound combines the reactivity of an aryl iodide with the electronic influence of a trifluoromethyl group. This unique structural combination makes it an indispensable reagent for constructing complex molecular architectures required in the pharmaceutical and agrochemical industries.
Our manufacturing process ensures exceptional batch-to-batch consistency, delivering a product that meets rigorous international standards for purity and performance. The presence of the iodine atom facilitates efficient oxidative addition in catalytic cycles, while the trifluoromethyl moiety enhances metabolic stability and lipophilicity in final drug candidates.
Key Chemical Features
This specialized intermediate offers several distinct advantages for process chemists and research laboratories. The high reactivity of the carbon-iodine bond allows for mild reaction conditions, reducing energy consumption and improving overall process safety. Furthermore, the electron-withdrawing nature of the trifluoromethyl group modulates the electronic density of the aromatic ring, enabling precise control over regioselectivity during substitution reactions.
- Superior reactivity in palladium-catalyzed cross-coupling reactions.
- Enhanced thermal stability suitable for diverse synthesis routes.
- High purity profile minimizing downstream purification burdens.
- Versatile applicability across medicinal chemistry and material science.
Technical Specifications
We maintain strict quality control protocols to guarantee the integrity of every shipment. The following table outlines the key physical and chemical parameters verified during our standard analysis.
| Parameter | Specification |
|---|---|
| Appearance | Light brown liquid |
| Assay (GC) | ≥98.0% |
| Water Content | ≤0.5% |
| Density | 1.851 g/mL at 25 °C |
| Boiling Point | 185-186 °C at 745 mm Hg |
| Molecular Formula | C7H4F3I |
| Molecular Weight | 272.01 g/mol |
Industrial Applications
The primary utility of 4-Iodobenzotrifluoride lies in its role as a precursor for active pharmaceutical ingredients (APIs). It is frequently employed in Suzuki-Miyaura, Heck, and Sonogashira coupling reactions to introduce fluorinated aryl groups into lead compounds. Beyond pharmaceuticals, this chemical serves as a vital component in the development of advanced agrochemicals and liquid crystal materials where specific electronic properties are required.
Research institutions value this intermediate for its reliability in method development and scale-up processes. The consistent quality provided by our global manufacturing network ensures that laboratory results translate smoothly to pilot plant and commercial production scales without unexpected variability.
Storage and Handling
To maintain optimal quality, this product should be stored in tightly closed containers within a cool, dry, and well-ventilated area. It is essential to keep the material away from sources of ignition, heat, and incompatible substances such as strong oxidizing agents. Standard laboratory safety practices, including the use of appropriate personal protective equipment, should be followed during handling to ensure personnel safety and environmental protection.
Our commitment to quality extends beyond the product itself. Each batch is accompanied by a comprehensive Certificate of Analysis (COA), providing full transparency regarding test results and compliance with factory standards. We invite partners to contact us for bulk pricing inquiries and technical support regarding specific synthesis applications.
