4-Methoxybenzoyl Chloride
- CAS No.100-07-2
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 4-Methoxybenzoyl Chloride (CAS 100-07-2) serving as a critical acylation agent for pharmaceutical intermediates like Amiodarone.
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Product Overview
4-Methoxybenzoyl chloride is a highly reactive organic compound belonging to the acyl chloride family, recognized extensively for its pivotal role in modern organic synthesis. Characterized by a methoxy substituent at the para position of the benzene ring, this chemical exhibits distinct reactivity profiles that make it indispensable for introducing the 4-methoxybenzoyl group into complex molecular structures. Our manufacturing process ensures exceptional purity levels, catering to the stringent requirements of fine chemical and drug substance production where consistency is paramount.
As a versatile electrophile, this compound facilitates efficient acylation reactions under controlled conditions. It is widely recognized for its stability when stored under anhydrous conditions and its capability to react selectively with nucleophiles such as amines and alcohols. The high quality of our supply chain guarantees consistent batch-to-batch performance, significantly reducing variability in downstream synthesis processes and ensuring reliable outcomes for research and production teams.
Technical Specifications
| Parameter | Value |
|---|---|
| CAS Number | 100-07-2 |
| Molecular Formula | C8H7ClO2 |
| Molecular Weight | 170.59 g/mol |
| Appearance | Colorless transparent liquid or solid |
| Assay | ≥99.0% |
| Boiling Point | 263.2±13.0 °C |
| Melting Point | 22 °C |
| Density | 1.2±0.1 g/cm3 |
| Loss on Drying | ≤0.5% |
| Flash Point | 87.8±0.0 °C |
Industrial Applications
The primary application of 4-Methoxybenzoyl chloride lies in the synthesis of active pharmaceutical ingredients (APIs). It serves as a critical intermediate in the production of Amiodarone hydrochloride, a well-known medication used for the treatment of arrhythmias, myocardial infarction, and angina pectoris. The precision required in cardiovascular drug manufacturing demands raw materials with minimal impurities, which our product delivers through rigorous quality control protocols.
Beyond cardiology, this reagent is utilized in the development of various agrochemicals and fine chemicals. Its ability to participate in Friedel-Crafts acylation and esterification reactions opens doors to diverse chemical architectures. Researchers and production managers value this compound for its reliable performance in scaling up laboratory processes to industrial manufacturing, ensuring that synthesis routes remain efficient and cost-effective.
Quality and Safety
Quality assurance is paramount in our production facility. Each batch undergoes comprehensive testing using advanced chromatographic methods to verify identity and purity. We provide a Certificate of Analysis (COA) with every shipment, detailing all critical parameters. Our facility adheres to international safety standards, ensuring that the manufacturing process minimizes environmental impact while maintaining product integrity.
Storage and Handling
- Store in a cool, dry, and well-ventilated area away from incompatible substances.
- Keep containers tightly closed to prevent moisture ingress, as the compound reacts violently with water.
- Avoid contact with strong bases, oxidizing agents, and alcohols during storage to prevent degradation.
- Use appropriate personal protective equipment (PPE) including gloves and eye protection when handling.
- Ensure storage containers are made of materials resistant to corrosion by acyl chlorides.
Our packaging options include 25kg drums, with customization available to meet specific logistical requirements. We prioritize safety and compliance in all shipping procedures to ensure the product arrives in optimal condition. Proper handling ensures the longevity of the chemical and the safety of personnel involved in its use.
