4'-Methyl-2-cyanobiphenyl
- CAS No.114772-53-1
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 4'-Methyl-2-cyanobiphenyl (CAS 114772-53-1) designed for pharmaceutical synthesis. Ideal intermediate for Losartan and Olmesartan production with guaranteed assay ≥99.0%.
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Product Overview
4'-Methyl-2-cyanobiphenyl is a critical organic building block extensively utilized in the pharmaceutical industry, specifically within the synthesis of Angiotensin II Receptor Blockers (ARBs). This high-value intermediate features a biphenyl structure substituted with a cyano group and a methyl group, providing the necessary chemical reactivity for downstream API manufacturing. Our facility produces this compound under strict quality control protocols to ensure consistency and reliability for large-scale pharmaceutical applications.
As a key precursor, the chemical integrity of 4'-Methyl-2-cyanobiphenyl directly influences the purity and efficacy of the final active pharmaceutical ingredient. We employ advanced catalytic coupling and purification technologies to minimize impurities, ensuring that each batch meets or exceeds international pharmacopoeia standards. This commitment to quality makes our product a preferred choice for generic drug manufacturers and research institutions globally.
Technical Specifications
| Parameter | Specification |
|---|---|
| Appearance | Off-white crystalline powder |
| Assay (GC) | ≥99.0% |
| Melting Point | 50-56°C |
| Moisture Content | ≤0.5% |
| 4,4-dimethyl biphenyl | ≤0.5% |
| Total Impurities | ≤1.0% |
| Molecular Formula | C14H11N |
| Molecular Weight | 193.24 g/mol |
Industrial Applications
The primary application of 4'-Methyl-2-cyanobiphenyl lies in the synthesis of antihypertensive medications, most notably Losartan and Olmesartan. These drugs are essential for managing high blood pressure and protecting kidney function in patients with diabetes. The cyano group on the biphenyl ring serves as a versatile handle for further functionalization, allowing chemists to construct the complex tetrazole or carboxylic acid motifs required for biological activity.
Beyond ARB synthesis, this intermediate is valuable in medicinal chemistry research where biphenyl scaffolds are needed for structure-activity relationship (SAR) studies. Its stability and defined reactivity profile enable robust synthetic routes, reducing waste and improving overall process efficiency. Manufacturers rely on our consistent supply to maintain uninterrupted production schedules for life-saving cardiovascular medications.
Quality Assurance and Packaging
We understand that pharmaceutical intermediates require rigorous documentation and handling. Every shipment of 4'-Methyl-2-cyanobiphenyl is accompanied by a comprehensive Certificate of Analysis (COA), detailing batch-specific test results against our strict internal specifications. Our quality assurance team conducts multi-point inspections during synthesis, crystallization, and drying to guarantee the reported assay and impurity profiles.
Standard packaging consists of 25 kg fiber drums lined with polyethylene bags to protect against moisture and contamination. Custom packaging solutions are available upon request to suit specific logistical needs. Storage recommendations include keeping the material in a cool, ventilated area away from direct sunlight and oxidizing agents. With a global logistics network, we ensure timely delivery to clients worldwide, supporting the continuous advancement of public health through reliable chemical supply chains.
