4-Methylsulfonylbenzaldehyde
- CAS No.5398-77-6
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
High-purity 4-Methylsulfonylbenzaldehyde (CAS 5398-77-6), a key pharmaceutical intermediate for the synthesis of chloramphenicol and thiamphenicol.
Request Bulk PricingProduct Technical Details
Product Overview
4-Methylsulfonylbenzaldehyde (CAS 5398-77-6) is a high-value aromatic aldehyde widely employed as a critical building block in the synthesis of advanced pharmaceutical intermediates. This compound features a methylsulfonyl group at the para position of the benzaldehyde ring, imparting enhanced reactivity and stability for use in multi-step organic transformations.
Specifications
| Molecular Formula | C8H8O3S |
|---|---|
| Molecular Weight | 184.21 g/mol |
| Appearance | Light yellow crystal powder |
| Purity | ≥99% |
| Moisture Content | ≤0.30% |
| Melting Point | 155–161 °C |
| Boiling Point | 378.3 °C at 760 mmHg |
| Density | 1.289 g/cm³ |
| Flash Point | 242.1 °C |
| Refractive Index | 1.544 |
Industrial Applications
As a versatile synthetic intermediate, 4-Methylsulfonylbenzaldehyde serves as a foundational precursor in the production of several important antibiotics. It is primarily utilized in the manufacturing pathways of chloramphenicol (CAS 56-75-7) and thiamphenicol (CAS 15318-45-3), both of which are broad-spectrum antimicrobial agents used in human and veterinary medicine.
Key advantages of this intermediate include:
- High chemical purity ensuring consistent reaction yields
- Excellent thermal and oxidative stability during storage and processing
- Compatibility with standard industrial-scale synthesis protocols
- Reliable performance in nucleophilic addition and condensation reactions
Handling and Storage
Store in a cool, dry, and well-closed container away from moisture, strong light, and heat sources. Proper handling in accordance with local regulatory guidelines is recommended to maintain product integrity and ensure workplace safety.
