4-Nitrophenyl Trifluoroacetate
- CAS No.658-78-6
- GradeIndustrial / Pharmaceutical
- Availability● In Stock
Premium grade 4-Nitrophenyl Trifluoroacetate designed for efficient organic synthesis and pharmaceutical intermediate production with guaranteed purity.
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Product Overview
4-Nitrophenyl Trifluoroacetate is a highly specialized chemical reagent widely recognized for its utility in organic synthesis and pharmaceutical manufacturing. As a robust trifluoroacetylating agent, this compound plays a critical role in the modification of amino groups and the activation of carboxylic acids during complex molecular constructions. Our facility produces this intermediate under strict quality control standards to ensure consistent performance in sensitive chemical reactions. The presence of the nitrophenyl group enhances the leaving group ability, making it an exceptional choice for esterification and amidation processes where high yields and purity are paramount.
We understand the demands of modern medicinal chemistry and process development. Therefore, our production lines are optimized to deliver material that meets rigorous specifications for research and industrial scale-up. Whether used in the synthesis of novel drug candidates or agrochemical intermediates, this product provides the reliability required for reproducible results. Our commitment to excellence ensures that every batch undergoes comprehensive analytical testing before release.
Key Specifications
| Parameter | Specification |
|---|---|
| Chemical Name | 4-Nitrophenyl Trifluoroacetate |
| CAS Number | 658-78-6 |
| Molecular Formula | C8H4F3NO4 |
| Molecular Weight | 235.12 g/mol |
| Appearance | Light yellow solid |
| Purity (GC) | ≥98.0% |
| Melting Point | 35-39°C |
| Boiling Point | 120°C |
| Density | 1.514 g/cm3 |
| Refractive Index | 1.486 |
Industrial Applications
This versatile intermediate finds extensive application across multiple sectors of the chemical industry. Its primary use lies in the pharmaceutical sector, where it serves as a key building block for introducing trifluoroacetyl groups into lead compounds. These modifications often improve metabolic stability and bioavailability of potential therapeutics. Additionally, it is employed in the preparation of activated esters for peptide coupling reactions, facilitating the efficient formation of amide bonds.
- Pharmaceutical intermediate synthesis for novel drug discovery
- Trifluoroacetylation of amines and alcohols in organic chemistry
- Activation agent for carboxylic acids in peptide synthesis
- Agrochemical intermediate production requiring high stability
- Research and development in fluorinated compound chemistry
Safety and Handling
Safety is our top priority during the production and distribution of 4-Nitrophenyl Trifluoroacetate. This substance is classified under Hazard Class 3 and should be handled with appropriate personal protective equipment. It is recommended to store the product in a cool, dry, and well-ventilated area away from incompatible materials such as strong oxidizing agents and moisture. Proper containment prevents hydrolysis and maintains the integrity of the reagent over time. We provide comprehensive safety data sheets with every shipment to ensure compliance with local regulations and safe handling practices.
Quality Assurance and Logistics
Our quality management system ensures that every lot of 4-Nitrophenyl Trifluoroacetate is accompanied by a Certificate of Analysis (COA). We utilize advanced gas chromatography and spectroscopic methods to verify identity and purity. Our global logistics network supports timely delivery with secure packaging that meets UN transportation standards. Clients can rely on our technical support team for assistance with application-specific queries or custom synthesis requirements. We strive to be a long-term partner in your supply chain, offering competitive bulk pricing without compromising on quality or service reliability.
